Title :
One-Nanosecond Overlap Coincidence Counting to Track PET Agents over Six Decades
Author :
Votaw, J.R. ; Nickles, R.J. ; Meyer, H.O. ; Hutchins, G.D. ; Satter, M.R.
Author_Institution :
Medical Physics Department, University of Wisconsin, Madison, WI Department of Physics, Indiana University, Bloomington, IN
Abstract :
Residue functions track the clearance of radio-labeled substrates through key metabolic pathways. Fast positron coincidence detection (BaF2, CsF) has a millihertz benchtop background. Subnanosecond resolution is preserved by delay-trimming NIM negative logic in a three-fold overlap "AND" circuit, enabling measurements over six decades of dynamic range on isolated animal preparations.
Keywords :
Animals; Delay; Detectors; Dynamic range; Energy resolution; Logic; Physics; Positron emission tomography; Time measurement; Timing;
Journal_Title :
Nuclear Science, IEEE Transactions on
DOI :
10.1109/TNS.1986.4337148
