Binding of semiconductor quantum dots to cellular integrins

Author

Alexson, D. ; Yang Li ; Ramadurai, D. ; Peng Shi ; George, Libin ; George, Libin ; Uddin, Muslem ; Thomas, Paul ; Rufo, S. ; Dutta, Maitreyee ; Stroscio, Michael A.

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Illinois, Chicago, IL, USA

Volume

3

Issue

1

fYear

2004

fDate

3/1/2004 12:00:00 AM

Firstpage

86

Lastpage

92

Abstract

There is currently a major international effort aimed at integrating semiconductor nanostructures with biological structures. This paper reports the functionalization of cadmium sulfide quantum dots with peptides that facilitate the selective binding of these quantum-dot-peptide complexes to integrins in the membranes of cancer cells of the MDA-MB-435 cell line. In addition, this paper focuses on the roles that biological environments play in altering and determining the optical and vibrational properties of these nanostructures.

Keywords

II-VI semiconductors; cadmium compounds; cellular biophysics; nanostructured materials; phonons; photoluminescence; semiconductor quantum dots; CdS; biological environments; biological structures; cadmium sulfide quantum dots; cancer cells; cellular integrins; integrating semiconductor nanostructures; nanostructure materials; optical properties; peptide complexes; semiconductor quantum dots binding; vibrational properties; Amino acids; Biomedical optical imaging; Cancer; Chemicals; Nanocrystals; Peptides; Quantum dots; Semiconductor nanostructures; Sequences; US Department of Transportation;

fLanguage

English

Journal_Title

Nanotechnology, IEEE Transactions on

Publisher

ieee

ISSN

1536-125X

Type

jour

DOI

10.1109/TNANO.2004.824030

Filename

1278274