Title :
Optical properties of wounds: diabetic versus healthy tissue
Author :
Papazoglou, Elisabeth S. ; Weingarten, Michael S. ; Zubkov, Leonid ; Zhu, Linda ; Tyagi, Som ; Pourrezaei, Kambiz
Author_Institution :
Sch. of Biomed. Eng. & Sci., Drexel Univ., Philadelphia, PA, USA
fDate :
6/1/2006 12:00:00 AM
Abstract :
Diffuse photon density wave (DPDW) methodology at Near Infrared frequencies has been used to calculate absorption and scattering from wounds of healthy and diabetic rats. The diffusion equation for semi-infinite media is being used for calculating the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain device. Differences observed during the course of healing in the two populations can be correlated to the delayed healing observed in diabetics. These results are encouraging and further work will focus on the implementation of this device to the clinical setting as a monitoring tool in chronic diabetic wounds.
Keywords :
absorption coefficients; bio-optics; biological tissues; biomedical equipment; diseases; patient monitoring; absorption coefficient; diabetic tissue; diffuse photon density wave; diffusion equation; frequency domain device; healthy tissue; monitoring tool; near infrared frequencies; optical properties; rats; scattering coefficient; semi-infinite media; wounds; Diabetes; Electromagnetic wave absorption; Equations; Frequency domain analysis; Frequency measurement; Optical scattering; Particle scattering; Phase measurement; Rats; Wounds; Diabetic wounds; diffuse photon density wave; near infrared spectroscopy (NIRS); Animals; Diabetes Complications; Diagnosis, Computer-Assisted; Equipment Design; Equipment Failure Analysis; Feasibility Studies; Female; Light; Rats; Spectrophotometry, Infrared; Wound Healing; Wounds, Penetrating;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2006.873541
