Title :
Preparation of Water-Dispersible and Biocompatible Iron Oxide Nanoparticles for MRI Agent
Author :
Lee, Yun Tack ; Woo, Kyoungja ; Choi, Kyu-Sil
Author_Institution :
Korea Inst. of Sci. & Technol., Seoul
fDate :
3/1/2008 12:00:00 AM
Abstract :
Highly monodisperse superparamagnetic iron oxide nanoparticles (SPIONs, 7.5 nm gamma- F2O3) were synthesized by thermal decomposition of iron pentacarbonyl and consecutive aeration in organic medium. By treating with a small amount of iron pentacarbonyl, Fe-rich surface has been formed on SPION. Water-dispersible SPIONs (SPION-MPA) were prepared by Fe-S covalent conjugation between Fe-rich SPION and mercaptopropionic acid (MPA) and then, transformed to SPION-MPA-dextran composite by physical adsorption of biocompatible polymer dextran. The hydrodynamic diameter of SPION-MPA-dextran was in the range of 225~237 nm in water. MR contrast and spin-spin relaxation intensity of our SPION-MPA-dextran were similar to those of the commercial products, Ferridex and Resovist.
Keywords :
adsorption; biomedical MRI; iron compounds; nanoparticles; nanotechnology; pyrolysis; spin-spin relaxation; superparamagnetism; Fe2O3; MPA; MRI agent; SPION-MPA-dextran composite; biocompatible iron oxide nanoparticles; biocompatible polymer dextran; iron pentacarbonyl; mercaptopropionic acid; monodisperse superparamagnetic iron oxide nanoparticles; physical adsorption; spin-spin relaxation; thermal decomposition; water-dispersible iron oxide nanoparticles; Dextran; MRI agent; SPION; Surface modification; surface modification;
Journal_Title :
Nanotechnology, IEEE Transactions on
DOI :
10.1109/TNANO.2007.909949
