DocumentCode :
951235
Title :
Protein-protein/DNA interaction networks: versatile macromolecular structures for the control of gene expression
Author :
Saiz, L. ; Vilar, J.M.G.
Author_Institution :
Dept. of Biomed. Eng., Univ. of California, Davis, CA
Volume :
2
Issue :
5
fYear :
2008
fDate :
9/1/2008 12:00:00 AM
Firstpage :
247
Lastpage :
255
Abstract :
The assembly of macromolecular structures consisting of proteins and DNA lies at the core of many fundamental cellular processes, such as transcription, recombination and replication. A common theme to all these processes is DNA looping, which provides the backbone for the required long-range interactions on DNA and results in further complexity that is exceptionally difficult to tackle with traditional quantitative approaches. Here, recent advances in mathematical and computational methods to study the assembly of protein-protein/DNA complexes with loops and their effects in the cellular behaviour through gene regulation are reviewed. The interplay between multisite DNA looping and DNA bending regulatory proteins, such as the catabolite activator protein (CAP), and on its physiological consequences is focused on. It has become clear in the last few years that the complexity that looping brings about can actively control transcriptional noise and cell-to-cell variability. Here, it is shown that the DNA looping, through the effects of CAP, can also control the balance between robustness and sensitivity of the induction of gene expression.
Keywords :
DNA; biochemistry; cellular biophysics; genetics; molecular biophysics; proteins; DNA bending; DNA looping; biochemical networks; catabolite activator protein; cell recombination; cell replication; cell transcription; cell-to-cell variability; fundamental cellular process; gene expression; long-range interactions; macromolecular structures; multisite DNA looping; protein-DNA interaction networks; protein-protein interaction networks; regulatory proteins; transcriptional noise;
fLanguage :
English
Journal_Title :
Systems Biology, IET
Publisher :
iet
ISSN :
1751-8849
Type :
jour
DOI :
10.1049/iet-syb:20080091
Filename :
4648906
Link To Document :
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