A High Field Gradient Magnet for Magnetic Drug Targeting

Author

Alexiou, Christoph ; Diehl, Dirk ; Henninger, Peter ; Iro, Heinrich ; Röckelein, Rudolf ; Schmidt, Wolfgang ; Weber, Horst

Author_Institution

Erlangen-Nurnberg Univ., Erlangen

Volume

16

Issue

2

fYear

2006

fDate

6/1/2006 12:00:00 AM

Firstpage

1527

Lastpage

1530

Abstract

A magnet for Magnetic Drug Targeting was designed, built and tested. The magnet applies a magnetic force on ferrofluids coupled with therapeutic agents for medical and biological applications, e.g. for regional treatment of cancer. The application for cancer treatment requires a high magnetic field gradient in the application volume around and inside the tumor. Furthermore the magnet should have low mass and size combined with an appropriate geometry for easy handling and positioning near the patient, as well as a surface temperature below 40 degC. The gradient of the magnetic field, which determines the magnetic force for small single-domain ferromagnetic particles, ranges from 100 T/m at the pole tip to a minimum of 10 T/m in an application volume of (20 mm)³ and points inwardly to the center of the pole tip

Keywords

cancer; drugs; ferromagnetic materials; magnetic fluids; magnets; nanoparticles; patient treatment; tumours; biological applications; cancer therapy; chemotherapy; ferrofluids; high field gradient magnet; magnet design; magnetic drug targeting; magnetic force; medical applications; nanoparticles; pole tip; regional cancer treatment; single-domain ferromagnetic particles; surface temperature; therapeutic agents; tumor; Cancer; Couplings; Drugs; Geometry; Magnetic fields; Magnetic forces; Medical treatment; Neoplasms; Surface treatment; Testing; Cancer therapy; chemotherapy; ferrofluid; magnet design; magnetic field gradient; magnetic force; nanoparticles;

fLanguage

English

Journal_Title

Applied Superconductivity, IEEE Transactions on

Publisher

ieee

ISSN

1051-8223

Type

jour

DOI

10.1109/TASC.2005.864457

Filename

1643145