Title :
Sensor for Stiffness Measurements Within the Adult Rat Hippocampus
Author :
Yang, Gloria Y. ; Wen, Yu-Hsin ; Földy, Csaba ; Tang, William C. ; Soltesz, Ivan
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of California, Irvine, CA
Abstract :
This paper presents a sensitive compliance measurement system for determining the stiffness of the adult rat hippocampus. The device has been successfully fabricated which consists of two strain gauges incorporated in the SU-8 based cantilever. The cantilever-sensor has been fully characterized and its strain sensitivity was found to be approximately 2.5. in vitro testing on the brain tissue has successfully demonstrated that the system is sufficiently sensitive to provide distinctive direct stiffness measurements on various hippocampal regions.
Keywords :
biological tissues; biomechanics; biomedical measurement; brain; diseases; mechanical variables measurement; neurophysiology; strain gauges; strain sensors; SU-8 based cantilever; adult rat hippocampus; brain tissue; cantilever-sensor; epilepsy; in vitro testing; neurological disorders; stiffness measurements; stiffness sensor; strain gauges; strain sensitivity; Anatomy; Biomedical measurements; Brain; Capacitive sensors; Head; Hippocampus; Mechanical factors; Neurons; Strain measurement; Testing; Brain; SU-8; cantilever; piezoresistive measurement; stiffness measurement;
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2008.2006472
