Title :
Ultrasonic cardiac pacing in the porcine model
Author :
Towe, Bruce C. ; Rho, Raymond
Author_Institution :
Dept. of Bioeng., Arizona State Univ., Tempe, AZ, USA
fDate :
7/1/2006 12:00:00 AM
Abstract :
Periodic pulses of intense ultrasound energy at 70 kHz with 5-ms duration at 3 MPa SPL applied to the exposed pig myocardium at physiologic rhythms were observed to produce cardiac pacing. Ten animals were successfully paced at pulse width and energy conditions above a certain threshold. Sigmoid strength-duration curves characterizing ultrasound´s effectiveness in pacing were observed to resemble those of electrical stimulation. We suggest that bioelectrical stimulatory effects of ultrasound on the heart are a radiation pressure effect and a manifestation of the known myocyte sensitivity to stretch.
Keywords :
bioelectric phenomena; biomedical ultrasonics; cardiology; muscle; radiation pressure; 5 ms; 70 kHz; bioelectrical stimulatory effects; electrical stimulation; exposed pig myocardium; heart; myocyte stretch sensitivity; porcine model; radiation pressure effect; sigmoid strength-duration curves; ultrasonic cardiac pacing; Acoustic pulses; Acoustic waves; Animals; Attenuation; Bioelectric phenomena; Frequency; Heart; Myocardium; Rhythm; Ultrasonic imaging; Radiation pressure stimulation; ultrasonic pacing; ultrasound bioelectric stimulation; Animals; Cardiac Pacing, Artificial; Equipment Design; Equipment Failure Analysis; Feasibility Studies; Heart Conduction System; Heart Rate; Models, Animal; Pacemaker, Artificial; Swine; Ultrasonic Therapy;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2006.875715
