DocumentCode :
979294
Title :
Relations Between Fractional-Order Model Parameters and Lung Pathology in Chronic Obstructive Pulmonary Disease
Author :
Ionescu, Clara M. ; De Keyser, Robin
Author_Institution :
Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent
Volume :
56
Issue :
4
fYear :
2009
fDate :
4/1/2009 12:00:00 AM
Firstpage :
978
Lastpage :
987
Abstract :
In this study, changes in respiratory mechanics from healthy and chronic obstructive pulmonary disease (COPD) diagnosed patients are observed from identified fractional-order (FO) model parameters. The noninvasive forced oscillation technique is employed for lung function testing. Parameters on tissue damping and elastance are analyzed with respect to lung pathology and additional indexes developed from the identified model. The observations show that the proposed model may be used to detect changes in respiratory mechanics and offers a clear-cut separation between the healthy and COPD subject groups. Our conclusion is that an FO model is able to capture changes in viscoelasticity of the soft tissue in lungs with disease. Apart from this, nonlinear effects present in the measured signals were observed and analyzed via signal processing techniques and led to supporting evidence in relation to the expected phenomena from lung pathology in healthy and COPD patients.
Keywords :
biological tissues; diseases; lung; physiological models; pneumodynamics; viscoelasticity; chronic obstructive pulmonary disease; elastance; forced oscillation technique; fractional-order model parameters; lung pathology; signal processing; tissue damping; viscoelasticity; Biological tissues; Damping; Diseases; Elasticity; Lungs; Pathology; Signal analysis; Signal processing; Testing; Viscosity; Demodulation; forced oscillations; fractional-order (FO) models; identification; input impedance; noninvasive; respiratory mechanics; signal processing; Adult; Biometry; Coal Mining; Humans; Lung; Lung Compliance; Models, Biological; Occupational Diseases; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Respiratory Mechanics;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2008.2004966
Filename :
4667643
Link To Document :
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