Design and feasibility study of a single photon emission microscope system for small animal I-125 imaging

Author

Meng, L.J. ; Clinthorne, N.H. ; Skinner, S. ; Hay, R.V. ; Gross, M.

Author_Institution

Dept. of Nucl. Eng., Michigan Univ., Ann Arbor, MI, USA

Volume

53

Issue

3

fYear

2006

fDate

6/1/2006 12:00:00 AM

Firstpage

1168

Lastpage

1178

Abstract

This paper presents a design study of a single photon emission microscope (SPEM) system for small animal imaging using I-125 labelled radiotracers. This system is based on the use of a very-high resolution gamma camera coupled to a converging non-multiplexing multiple pinhole collimator. This enables one to "zoom" into a small local region inside the object to extract imaging information with a very high spatial resolution and a reasonable sensitivity for gamma rays emitted from this local region. The SPEM system also includes a pinhole (or multiple pinhole) gamma camera that has a full angular coverage of the entire object. The designed imaging spatial resolution for the SPEM system is between 250 μm to 500 μm FWHM.

Keywords

cameras; collimators; gamma-ray detection; image resolution; radioactive tracers; single photon emission computed tomography; I-125 labelled radiotracers; SPECT; converging nonmultiplexing multiple pinhole collimator; gamma-ray emission; multiple pinhole gamma camera; single photon emission microscope system study; small animal I-125 imaging; very-high spatial resolution gamma camera; Animals; Apertures; Cameras; Collimators; Detectors; High-resolution imaging; Microscopy; Optical imaging; Single photon emission computed tomography; Spatial resolution; Converging non-multiplexing multiple pinhole aperture; microscope; very-high spatial resolution gamma camera;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/TNS.2006.871405

Filename

1645012