Title :
Ultra-sensitive immunoassay using VCSEL detection system
Author :
Mateus, C.F.R. ; Huang, M.C.Y. ; Chang-Hasnain, C.J. ; Foley, J.E. ; Beatty, R. ; Li, P. ; Cunningham, Brian T.
Author_Institution :
Electr. Eng. & Comput. Sci. Dept., Univ. of California, Berkeley, CA, USA
fDate :
5/27/2004 12:00:00 AM
Abstract :
Highly sensitive protein characterisation on a new label-free biosensor system is reported. The system consists of a VCSEL, a plastic guided mode resonant filter and two pin detectors. It is suitable for measuring both static and dynamic interaction among proteins and can detect an antigen concentration as low as 1 pg/ml (6.7 femtoMolar).
Keywords :
biosensors; molecular biophysics; proteins; resonator filters; surface emitting lasers; VCSEL detection system; antigen concentration; dynamic interaction; label free biosensor system; pin detectors; plastic guided mode resonant filter; protein characterisation; proteins; static interaction; ultra sensitive immunoassay; vertical cavity surface emitting layer;
Journal_Title :
Electronics Letters
DOI :
10.1049/el:20040491
