ﺗﺄﺛﯿﺮ ﺗﻤﺮﯾﻨﺎت ﻣﺨﺘﻠﻒ ورزﺷﯽ ﺑﺮ ﻋﻤﻠﮑﺮد اﻧﺪوﺗﻠﯿﺎل ﻋﺮوق؛ ﻣﺘﺎآﻧﺎﻟﯿﺰ ﻣﻄﺎﻟﻌﺎت داﺧﻞ و ﺧﺎرج از ﮐﺸﻮر

Effects of Different Exercise Training on Vascular Endothelial Function- Meta Analysis Iranian and International Studies

ﻫﺪف از ﭘﮋوﻫﺶ ﺣﺎﺿﺮ، ﻣﺘﺎآﻧﺎﻟﯿﺰ ﻣﻄﺎﻟﻌﺎت اﻧﺠﺎمﮔﺮﻓﺘﻪ درزﻣﯿﻨﮥ اﺛﺮﺑﺨﺸﯽ ﺗﻤﺮﯾﻨﺎت ﻣﺨﺘﻠﻒ ورزﺷﯽ ﺑﺮ ﻋﻤﻠﮑﺮد اﻧﺪوﺗﻠﯿﺎل ﻋﺮوق ﺑﻮد. ﺑﺮاي ﺑﺮرﺳﯽ ﻣﻄﺎﻟﻌﺎت اﻧﺠﺎمﺷﺪه درﻣﻮرد ﻋﻤﻠﮑﺮد اﻧﺪوﺗﻠﯿﺎل ﻋﺮوق، ﺟﺴﺘﺠﻮ در ﭘﺎﯾﮕﺎهﻫﺎي اﻃﻼﻋﺎﺗﯽ ﭘﺎبﻣﺪ، ﺳﺎﯾﻨﺲ داﯾﺮﮐﺖ، اﺳﮑﻮﭘﻮس، وب آو ﺳﺎﯾﻨﺲ، اس.آي.دي، ﻣﮓ اﯾﺮان و ﮔﻮﮔﻞ اﺳﮑﻮﻻر ﺑﺎ ﮐﻠﻤﺎت ﮐﻠﯿﺪي ﻣﺸﺨﺺﺷﺪه ﺑﯿﻦ ﻣﻘﺎﻻﺗﯽ ﮐﻪ ﻃﯽ ﺳﺎلﻫﺎي (1986) ﺗﺎ (2016) ﺑﻪ زﺑﺎنﻫﺎي ﻓﺎرﺳﯽ و اﻧﮕﻠﯿﺴﯽ ﻣﻨﺘﺸﺮ ﺷﺪه ﺑﻮدﻧﺪ، اﻧﺠﺎم ﮔﺮﻓﺖ. ﭘﺲ از ﻏﺮﺑﺎلﮔﺮي اوﻟﯿﻪ، ﺑﺮرﺳﯽ ﻣﺘﻦ ﮐﺎﻣﻞ و ارزﯾﺎﺑﯽ ﻧﻘﺎداﻧﮥ ﻣﻄﺎﻟﻌﺎت، ﻣﻘﺎﻻﺗﯽ ﮐﻪ داراي ﻣﻌﯿﺎرﻫﺎي ورود ﺑﻪ ﭘﮋوﻫﺶ ﺑﻮدﻧﺪ، ﻣﻮردآﻧﺎﻟﯿﺰ ﻗﺮار ﮔﺮﻓﺘﻨﺪ و درﻧﻬﺎﯾﺖ، 14 ﭘﮋوﻫﺶ ﮐﻪ ﺷﺎﻣﻞ 17 ﮐﺎرآزﻣﺎﯾﯽ ﺑﺎ ﻣﻌﯿﺎرﻫﺎي ورود ﺑﻪ ﻣﺘﺎآﻧﺎﻟﯿﺰ ﺑﻮد، آﻧﺎﻟﯿﺰ ﮔﺮدﯾﺪ. ﻧﺘﺎﯾﺞ ﻣﺘﺎآﻧﺎﻟﯿﺰ ﻧﺸﺎن ﻣﯽدﻫﺪ ﮐﻪ روشﻫﺎي ﻣﺨﺘﻠﻒ ﺗﻤﺮﯾﻨﯽ ﻣﯽﺗﻮاﻧﺪ ﻣﻮﺟﺐ ﺑﻬﺒﻮد ﺷﺎﺧﺺ اﺗﺴﺎع ﻋﺮوﻗﯽ واﺑﺴﺘﻪ ﺑﻪ ﺟﺮﯾﺎن ﺧﻮن در آزﻣﻮدﻧﯽﻫﺎي ﺳﺎﻟﻢ (اﻧﺪازه اﺛﺮ 0/84 و ﺳﻄﺢ ﻣﻌﻨﺎداري 0/001) و اﻓﺮاد ﻣﺒﺘﻼ ﺑﻪ ﺑﯿﻤﺎري ﺷﺮﯾﺎن ﮐﺮوﻧﺮ (اﻧﺪازه اﺛﺮ 0/49 و ﺳﻄﺢ ﻣﻌﻨﺎداري 0/001) ﮔﺮدد. ازﺳﻮيدﯾﮕﺮ، اﮔﺮﭼﻪ اﻧﺪازة اﺛﺮ ﺑﻪدﺳﺖآﻣﺪه ﺑﺮاي ﺗﻤﺮﯾﻨﺎت ورزﺷﯽ ﻣﺨﺘﻠﻒ ﺑﺎ ﯾﮑﺪﯾﮕﺮ ﻣﺘﻔﺎوت اﺳﺖ؛ اﻣﺎ ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺗﻌﺪاد ﭘﺎﯾﯿﻦ ﻣﻄﺎﻟﻌﺎت ﻧﻤﯽﺗﻮان درﻣﻮرد ﺑﺮﺗﺮي ﯾﮏ روش ﺗﻤﺮﯾﻨﯽ اﻇﻬﺎرﻧﻈﺮ ﻗﻄﻌﯽ ﻧﻤﻮد. ﺑﻪﻃﻮرﮐﻠﯽ، ﻣﯽﺗﻮان ﮔﻔﺖ ﮐﻪ ﺗﻤﺮﯾﻨﺎت ورزﺷﯽ ﻣﯽﺗﻮاﻧﺪ در ﺑﻬﺒﻮد ﻋﻤﻠﮑﺮد اﻧﺪوﺗﻠﯿﺎل ﻋﺮوق ﻣﺆﺛﺮ ﺑﺎﺷﺪ؛ اﮔﺮﭼﻪ ﺑﺎز ﻫﻢ ﻧﯿﺎز ﺑﻪ ﻣﻄﺎﻟﻌﺎﺗﯽ ﺑﺎ ﮐﯿﻔﯿﺖ ﺑﺎﻻ و ﺣﺠﻢ ﻧﻤﻮﻧﮥ ﮐﺎﻓﯽ دراﯾﻦزﻣﯿﻨﻪ اﺣﺴﺎس ﻣﯽﺷﻮد.

The aim of this peper was meta-analysis of studies on the effectiveness of different exercise training on vascular endothelial function. To assessment studies in the field of vascular endothelial function search was done in databases; PubMed, scienceDirect, Scopus, Web of science, SID, Magiran and google Scholar with specified keywords among articles that were published in the years 1986 to 2016 both in Persian and English. After initial screening, full text search and critical appraisal, studies which pass the inclusion criteria were analyzed. Among imported article, 14 study which included 17 trials with meta-analysis inclusion criteria were analyzed. The results of the meta-analysis of studies showed that exercise can improve flow mediated dilation in healthy subjects (SMD=0.75, 95% CI 0.49–1.00, P=0.001) and patients with coronary artery disease (SMD=0.47, 95% CI 0.29–0.65, P=0.001). Although the effect size obtained for various exercise training are different, but considering the low number of studies, we cannot make an absolute statement about the superiority of one method of training. The exercise can be effective in improving endothelial function, although still high-quality research studies with sufficient sample size is needed.