تاثير فعاليت مقاومتي و حجم آن بر غلظت پلاسمايي ويسفاتين و ارتباط آن با مقاومت به انسولين، اينترلوكين-6 و هورمون رشد در مردان جوان

Effect of resistance exercise and its volume on plasma visfatin concentration and its relationship with insulin resistance index, interlukin-6 and growth hormone in men

هدف: هدف تحقيق حاضر بررسي پاسخ غلظت پلاسمايي ويسفاتين به حجم فعاليت مقاومتي و ارتباط آن با مقاومت به انسولين، هورمون رشد وIL-6 مي باشد. روش شناسي: پانزده مرد جوان سالم (سن 1±23/9 سال، وزن 7/2±74/4 كيلوگرم، شاخص توده بدني 3/6±26/1 كيلوگرم بر متر مربع) در تحقيق حاضر شركت نمودند. بعد از تعيين 10-RM، آزمودني ها دو جلسه فعاليت مقاومتي 3 نوبت و 5 نوبتي را با فاصله يك هفته و بطور تصادفي اجرا نمودند. سه نمونه خوني قبل و بعد از فعاليت و نيز بعد از 30 دقيقه ريكاوري گرفته شدند و براي اندازه گيري هورمون رشد، اينترلوكين-6 و ويسفاتين آناليز شدند. مقاومت به انسولين نيز با استفاده از غلظت گلوكز و انسولين محاسبه گرديد. براي مقايسه جداگانه داده هاي قبل و بعد از ورزش و بعد از ريكاوري در دو جلسه، از آزمون آناليز واريانس 3×2 مكرر استفاده شد. يافته ها: نتايج نشان داد كه بين پاسخ پلاسمايي ويسفاتين، اينترلوكين -6 و شاخص مقاومت به انسولين به دو حجم متفاوت فعاليت مقاومتي تفاوت معني داري وجود ندارد (0/05p) بررسي همبستگي آماري داده ها در پاسخ به فعاليت، ارتباط معني داري را بين هيچ كدام از متغيرهاي اندازه گيري شده با ويسفاتين نشان نداد (0/05

Introduction: The aim of the present study was to investigate the responses of plasma visfatin to resistance exercise volume and its relationship with insulin resistance index, IL-6 and growth hormone. Methods: Fifteen healthy young subjects (age: 23.9±1, weight: 74.4±7.2, BMI: 26.1±3.6) were volunteered to participate in the study. After familiarization and determining the maximum strength (1-RM), subjects performed two resistance exercise protocols of 3-sets and 5 sets randomly at two separate occasions with one week intervening. Three blood samples were taken before exercise, immediately after exercise and after 30 min recovery, and were analyzed for growth hormone, interlukin- 6 (IL-6) and visfatin. Insulin resistance index was calculated using glucose and insulin concentrations. To compare the responses of parameters to exercise and recovery, the differences between pre and post exercise as well as pre and post recovery data were calculated and compared by using paired t-test. Results: Results showed that there were no significant differences between the responses of these parameters to two resistance exercise volumes (P>0.05). Irrespective of resistance exercise volume, single session of resistance exercise resulted in significant (P<0.001) changes in all variables except for visfatin. Investigating the statistical correlations of data in response to exercise showed no significant relationship among all variables with visfatin. Conclusions: The results of this study show that resistance exercise volume is not an affective factor on plasma concentration of visfatin and that visfatin cannot be considered as one of the affective factors in insulin resistance process.