برهم كنش برخي مواد مغذي با هريك از پلي مورفيسم هاي CCND2، ZNT8 و MC4R در رابطه با خطر سندرم متابوليك و هر يك از اجزاء آن

The Interaction Between Some Nutrients and CCND2, ZNT8, and MC4R Polymorphisms in Relation to Metabolic Syndrome and Its Components

سابقه و هدف: هدف از اين مطالعه بررسي برهم كنش برخي از مواد مغذي )درشت مغذي ها و ريز مغذي ها شامل منيزيم، روي، آهن، كلسيم و مس( با پلي مورفيسم هاي 11063069CCND2 rs، 13266634rs ZNT8 و 12970134rs MC4R در ارتباط با سندرم متابوليك و اجزاي آن مي باشد. مواد و روش ها: در اين پژوهش مورد- شاهدي لانه گزيده همسان شده، اطلاعات 1634 نفر، 817 جفت مورد (موارد جديد ابتلا به سندرم متابوليك)- شاهد (افراد سالم بدون سندرم متابوليك) از ميان شركت كنندگان مطالعه قند و ليپيد تهران انتخاب شدند. افراد مورد و شاهد از نظر سن، جنس و سال هاي پيگيري همسان شدند. دريافت هاي تغذيه اي از طريق پرسشنامه روا و پايا بسامد خوراك به دست آمد. پلي مورفيسم ها به روش ARMS-PCR تعيين ژنوتيپ شدند. استنتاج: مصرف رژيم هاي كم چرب به حاملين الل A از پلي مورفيسم 12970134rs توصيه مي شود، در حالي يك رژيم غني از روي و امگا 3 براي حاملين الل Cاز پلي مورفيسم 13266634rs مناسب تر است.

Background and purpose: This study aimed at examining the interaction between macronutrients, some micronutrients (magnesium, zinc, iron, calcium, and copper) and CCND2 rs11063069, ZNT8 rs13266634, and MC4R rs12970134 polymorphisms in relation to metabolic syndrome (MetS) and its components. Materials and methods: In this matched nested case-control study, the data for 1634 (817 pairs) case (the new cases of metabolic syndrome) and controls (healthy individuals without metabolic syndrome) were obtained from the Tehran Lipid and Glucose Study. The participants were matched on age, sex, and follow-up years. Dietary intakes were assessed using the Food Frequency Questionnaire (FFQ). The polymorphisms were genotyped by ARMS-PCR. Results: Saturated fatty acid and omega-3 fatty acid could modulate the association of MC4R and ZNT8 variant with MetS, respectively (Pi<0.05). There was a significant interaction between MC4R rs12970134 with total fat intake and abdominal obesity (Pi=0.01). Also, significant interaction was observed between rs13266634 with omega 3 fatty acid and poly-unsaturated fatty acid on the risk of dyslipidemia (high TG and low HDL-C) and high fasting blood glucose, respectively (Pi<0.05). Among micronutrients examined in this study, iron and zinc modified the association of MC4R and ZNT8 variant with abdominal obesity and high fasting blood glucose, respectively (Pi<0.05). Conclusion: According to our findings, low fat diets are recommended in A allele carriers of MC4R rs12970134, while a diet rich in omega-3 and zinc is more appropriate for C allele carriers of ZNT8 rs13266634.