پديد آورندگان :
Norouzi، Neda Center of excellence for Biodiversity - Faculty of natural sciences Center of excellence for Biodiversity - University of Tabriz , Bonyadi, Mortaza Center of excellence for Biodiversity - Faculty of natural sciences Center of excellence for Biodiversity - University of Tabriz , Babaei, Esmaeil Department of animal biology - school of natural science - University of Tabriz , Jabbarpour Bonyadi, Mohammad Hosein Ophthalmic Research Center - Shaheed Beheshti University of Medical Sciences & Health Services , Javadzadeh, Alireza Department of Ophthalmoiogy - Nikookari Eye Hospital - Tabriz University of Medical Scinces
چكيده فارسي :
Background and Aims
To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).
Materials and Methods
In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
Results
Investigation of the association of p.Gly119Arg polymorphism in CFI gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).
Conclusion
Our result show that p.Gly119Arg polymorphism of the CFI gene is unrelated to the susceptibility to AMD in Northwest of Iran
