چكيده فارسي :
هيرسوتيسم در بسياري از موارد يك مشكل زيبائي در خانمها بوده ولي در مواردي نيز بدنبال اختلالات هورموني ناشي از يكسري مسائل هورموني همانند بدكاري تخمدانها، غدد فوق كليوي ، عوامل هيپوفيزي و يا مصرف داروها بوجود ميآيد . ضمن اينكه ميتواند با مشكلات جديتري همچون نازائي و يا بدخيميهاي غدد فوق نيز همراه باشد . لذا در برخورد با اينگونه بيماران به دو نكته اساسي فوق يعني بيماري يابي و نيز رفع حالت ناخوشايند آن از نظر زيبايي كه ميتواند در سرنوشت خانمهاي جوان موثر باشد توجه نمود . در برخورد با اين بيماران توجه به وجود حالت مشابه در بستگان درجه 1 ، وضعيت جثه (Body mass index ) ، شدت و انتشار پر موئي و وجود الوپسي و يا نازائي و سابقه مصرف دارو و همراهي آن با امراض غددي ديگر اهميت پيدا ميكند و در كاوشهاي پاراكلينيك اندازهگيري تستوسترون سرم، پرولاكتين ، كورتيزول ، DHEA - S04 ونيز سونوگرافي جهت وجود كيستهاي تخمدان اهميت پيدا ميكند • البته در اغلب موارد علت خاصي براي آن پيدا نشده و مساله فوق ميتواند مشكل ارثي و نژادي باشد كه جهت درمان موارد اخير اپيلاسيون موها توصيه ميشود . تعريف : رشد موهاي زبر با حالت مردانه را در خانمها به طور كلي يا نسبي هيرسوتيسم مينامند . اين تغييرات وابسته به آندروژن بوده كه نه فقط وابسته به تخمدان است بلكه تحت تاثير عوامل سن ، ديانسفال ، غده هيپوفيز و غده فوق كليه نيز قرار دار
چكيده لاتين :
Dr. Mir Hadi Aziz Jalali. Department of Dermatology, Razi Hospital Gilan University of Medical Sciences.
Today hirsutism is one of the problems of pateints referring to dermatologic & Endocrinologic clinics.
In 107 hirsute women the following indexes were investigated : age, marital status, menstruation rate of fertility , weight , similar problems in first grade relatives , distribution of hirstism (face , chin, chest ), alopecia , history of using drugs such as hormones psychotrops habit of smoking, coincident diseases, meosurement of serum testosteron, prolactin , cortisol and dehydroepiandrosteronedione levels and in suspicious cases sonography of ovaries is porfor meal.
From statistical analysis, Age distribution in 93% were between 15 - 35, mensaruttion irregularity 33% and unmarried cases 67% and from 33% married hirsutes , 70% had children, 19% were obese and in 57% similar problem could be seen in first grade relatives of patients.
Distribution of hirsutism was 46% in chin 13% in mandible and chin 21% in facial region .and 20% in chest and facial area .Alopecia in 10% could be considered coincidently , in 13% of cases history of using drugs such as hormones ( medroxyprogestron , Clomiphene , thyroid extract), and psychotrops ( chlordiazepoxide , diazepam , Amitriptyline, Trifluperazine, phenytoin and phenobarbital ) were positive. Only 10% of patients were smoker , in 14% of cases history of other diseases such as goiter , renal calculus , urinary tract infection peptic ulcer, could be found.
Also 4 cases of these hirsutes were suffering of infertility and in 5 cases ovarian cysts thickening of its surfaces detected from laboratory tests. Increasing of testosterone (21%) , prolactin (22%) cortisol(9%), and D.H.E.A (9%) were considered. No hormonal abnor mality were detected in 43 of 107 cases in our study.