ارتباط واريته rs763780 ژن اينترلوكين 17F با ريسك ابتلا به استئوآرتريت زانو

Association of rs763780 variation in interleukin 17F gene with the risk of knee osteoarthritis

سابقه و هدف آسيب هاي ناشي از استئوآتريت به وسيله انواع سيتوكين ها، فاكتور هاي رشد و واسطه هاي التهابي ميانجي گري شده و اهميت خانواده اينترلوكين 17 در اين بيماري به طور فزاينده اي آشكار است. هدف از اين مطالعه بررسي ارتباط واريته rs763780 ژن اينترلوكين 17F با ريسك ابتلا به استئوآرتريت زانو مي باشد. مواد و روش ها در اين پژوهش مورد-شاهدي 200 شركت كننده شامل 100 فرد سالم و 100 فرد مبتلا به استئوآرتريت زانو مراجعه كننده به بيمارستان شهيد بهشتي كاشان وارد مطالعه شدند. بعد از جمع آوري نمونه هاي خون از افراد شركت كننده در مطالعه، ژنوتايپ نمونه ها در محل پلي مورفيسم فوق به وسيله روش PCR-RFLP تعيين شد. نتايج آناليز داده ها نشان داد كه ارتباط معناداري بين ژنوتايپ AG با افزايش ريسك ابتلا به استئوآرتريت زانو وجود داشته (0/01

Background: The injuries in osteoarthritis are mediated by various cytokines, growth factors, and inflammatory factors and the importance of the interleukin 17 family in this disease is increasingly evident. The aim of this study was to investigate the association between interleukin 17F rs763780 gene variation and the risk of knee osteoarthritis. Materials and Methods: In this case-control study, 200 participants including 100 healthy individuals and 100 patients with knee osteoarthritis referred to Shahid Beheshti hospital were enrolled. The blood samples of the participants were collected and genotypes of the samples in the polymorphic region were detected by PCR-RFLP. Results: Results showed that there was a significant association between the genotype AG and an increased risk of knee osteoarthritis (OR=3.49, 95%CI=1.48-8.25, P<0.01). But, no significant association was found between the genotype GG and an increased risk of knee osteoarthritis. In addition, there was a significant association between the allele G and the risk of knee osteoarthritis (OR=2.97, 95% CI=1.39-6.30, P<0.01). Conclusion: Findings of the present study show that rs763780 can be a risk factor for knee osteoarthritis. Therefore, this polymorphism can be considered as a possible biomarker for the screening of susceptible individuals to knee osteoarthritis.