مطالعه ميزان التهاب ايجاد شده ناشي از تزريق داخل مفصلي كايولين در خرگوش طي زمان هاي مختلف

A Study on the Inflammatory Effect of Intra-articular Injection of Kaolin in the Rabbitʹs Knee Joint at Different Time Periods

The present study was performed on male white Dutch rabbits weighing from 1.5-2 kg. Animals were anaesthetized by ether and Evans blue (75mg/kg) was injected into the marginal ear vein. Acute inflammation of the rabbit knee joint was induced by intra-articular injection of 4% kaolin. Evans blue injection was used as a marker for the amount of protein extravasation into the tissue. The effect of kaolin (4%) was studied 2,4, 6, 8 and 24 hours after injection. Kaolin induced maximum inflammation 4 hours after injection. The rate of inflammation was gradually reduced after 4 hours. The present result indicates that kaolin (4%) can induce maximum inflammation 4 hours after injection.