بررسي اثرات اسانس سماق بر افسردگي و اضطراب در موش هاي صحرايي نر

Effects of Rhus Coriaria essential oil on depression and anxiety in male rats

سابقه و هدف افسردگي و اضطراب جزء بيماري هاي مهم گريبان گير بشر هستند. داروهاي شيميايي مورد استفاده در درمان اين بيماري ها داراي عوارض جانبي بوده، به همين دليل استفاده از گياهان دارويي نظير سماق، باتوجه به خواصي نظير خاصيت ضداكسيداني، احتمالا مي تواند در درمان اين بيماري ها موثر واقع شود. در اين مطالعه اثر تجويز خوراكي اسانس ميوه سماق بر افسردگي و اضطراب در موش هاي صحرايي نر بررسي شد. مواد و روش ها در اين مطالعه تجربي، موش هاي صحرايي نر بالغ نژاد ويستار به گروه هاي: كنترل، اسانس سماق (با دوزهاي 50، 100 و mg/kg 300، فلوكستين (داروي رفرنس افسردگي) و آلپرازولام (داروي رفرنس اضطراب) تقسيم شدند. جهت سنجش افسردگي از تست شناي اجباري و جهت سنجش اضطراب از تست ماز به علاوه شكل مرتفع استفاده شد. نتايج در تست شناي اجباري، مابين گروه اسانس سماق (100 و 300 ميلي گرم بر كيلوگرم) و گروه كنترل از نظر مدت زمان بي حركتي (به ترتيب با: 0/05

Background: Depression and anxiety are among the most important diseases of human being. The chemical drugs used to treat these diseases have side effects, therefore, the use of medicinal herbs such as Rhus Coriaria can be effective in treating these diseases with regard to properties such as anti-oxidant activity. In this study, the effects of oral administration of Rhus Coriaria fruit essential oil (RCFEO) was investigated on depression and anxiety in male rats. Materials and Methods: In this experimental study, adult male Wistar rats were divided into control, RCFEO (50, 100, and 300 mg/kg), fluoxetine (depression reference drug) and alprazolam (anxiety reference drug) groups. In order to evaluate the depression and anxiety, forced swimming and elevated plus maze tests were used, respectively. Results: In the forced swimming test, there were significant differences between the RCFEO (100 and 300 mg/kg) and the control group in aspect of the immobility time (P<0.05, P<0.001) as well as climbing time (P<0.05, P<0.01), respectively. In addition, the results from the elevated plus maze test showed that the percent of entries into open arms are significantly different between 300 mg/kg of RCFEO and control that way this index had increased by using RCFEO (300 mg/kg) (P<0.001). Conclusion: This experimental study indicates that administration of Rhus Coriaria fruit essential oil (orally) probably can improve depression and anxiety in male rats.