اثر گياهان گل اشرفي، صبرزرد و كرچك بر روند التيام زخم‌هاي پوستي در موش صحرايي نر بالغ

The Effect of Calendula, Aloe and Caster on Cutaneous Wounds Healing Process in Mature Male Rat

زمينه و هدف: زخم‌هاي پوستي بسيار دردناك اند و درمان آنتي‌بيوتيكي آن‌ها هزينه بر و داراي عوارض جانبي است. امروزه گياهان دارويي به علت قيمت و عوارض كمتر به صورت گسترده استفاده مي‌شوند. گياهان گل اشرفي، صبرزرد و كرچك داراي خواص ضدميكروبي و التيامي هستند. هدف از مطالعه حاضر مقايسه اثر اين سه گياه دارويي بر روي روند ترميم زخم پوستي در موش صحرايي نر مي‌باشد. مواد و روش‌ها: در مطالعه تجربي حاضر، 32 موش صحرايي نر بالغ به روش تصادفي به چهار گروه 8 تايي تقسيم شدند كه شامل يك گروه كنترل (گروه زخم و استعمال موضعي ناحيه آسيب ديده با اوسرين) و سه گروه تحت درمان با گل اشرفي، صبرزرد و كرچك (استعمال موضعي با 2 سي‌سي عصاره 10 درصد) بود. زخم‌هايي با ضخامت‌هاي مساوي در ناحيه پشتي موش‌ها ايجاد و قطر آن‌ها در طول درمان (21 روز) اندازه گيري و در پايان نمونه‌هاي بافتي نيز تهيه شد. داده‌ها توسط آزمون‌ آماري آنواي يك طرفه و تعقيبي توكي آناليز شدند. يافته‌ها: اندازه قطر زخم‌ها در روز پنجم نشان داد كه ميانگين مساحت زخم در گروه تحت درمان با گل اشرفي و كرچك به طور معني‌داري كمتر از گروه كنترل بود (0/05

Background and Objectives: Cutaneous wounds are seriously painful and their antibiotic treatments are expensive with adverse effects. Nowadays medicinal herbs are widely used because of lower cost and side effects. Calendula officinalis, Aloe arborescens and Ricinus communis herbs have antimicrobial and healing effects. The aim of the present study was comparing the effect of these three herbal medicines on cutaneous wound healing process in male rat. Materials and Methods: In this experimental study, 32 male adult rats were randomly divided into 4 equal groups of 8, including one control group (wound group and topical use of eucerine in the injured area) and three groups treated with Calendula officinalis, Aloe arborescens and Ricinus communis (topical use of 2cc extract 10%). Wounds with equal thickness were made on the rats’ back sides and their diameters were measured in the treatment period (21 days) and tissue samples were finally prepared. Data were analyzed by one-way ANOVA and Tukey's post hoc test. Results: Diameter measures of the wounds on the 5th day showed that the average of the wounds’ diameters in the Calendula officinalis and Ricinus communis treated groups were significantly lower than the control group (p<0.05). At the end of the experiment, the best improvement on cutaneous wound healing belonged to the group treated with Ricinus communis so that there was a significant difference between this group and the control group (p<0.05). Conclusion: Ricinus communis medicinal herb has more improving effect on cutaneous wound healing in rat.