كاربرد باليني بيولوژي سرطان پستان مروري بر مقالات و منابع پزشكي

Clinical Application of Breast Cancer Biology Review of Literature

ﺯﻣﻴﻨﻪ ﻭ ﻫﺪﻑ: ﺩﺳﺘﻪ ﺑﻨﺪﻱ ﻭ ﻛﺎﺭﺑـﺮﺩﻱ ﻛـﺮﺩﻥ ﺣﺠـﻢ ﺯﻳـﺎﺩ ﻭ ﺭﻭﺯﺍﻓـﺰﻭﻥ ﺍﻃﻼﻋـﺎﺕ ﺩﺭ ﺯﻣﻴﻨﺔ ﺯﻳﺴﺖ ﺷﻨﺎﺳـﻲ ﺳﺮﻃﺎﻥ ﭘﺴﺘﺎﻥ، ﺭﺍﻫﻨﻤـﺎﺋﻲ ﻧﺤـﻮﺓ ﺍﺳﺘﻔـﺎﺩﻩ ﺍﺯ ﺣﺎﺻـﻞ ﺍﻧﺒـﻮﻩ ﺍﻛﺘﺸﺎﻓـﺎﺕ ﺑﻴﻮﻟـﻮﮊﻳﻚ ﺟـﺪﻳﺪ ﺳﺮﻃﺎﻥ ﭘﺴﺘـﺎﻥ ﻭ ﺍﻧﺘﻘـﺎﻝ ﺁﻥ ﺑﻪ ﺟـﺮﺍﺣﺎﻥ ﺑﺮﺍﻱ ﻋﻤﻠﻜـﺮﺩ ﺭﻭﺯﺍﻧﻪ. ﻣﻮﺍﺩ ﻭ ﺭﻭﺵ ﻫﺎ: ﺗﻌﺪﺍﺩ 1836 ﻣﻘﺎﻟﻪ ﺍﺯ ﺳﺎﻝ 1986 ﻟﻐﺎﻳﺖ 2008 ﺑﺮﺭﺳﻲ ﺷﺪﻧﺪ. ﺍﺯ ﺑﻴﻦ 837 ﻣﻘﺎﻟﻪ ﺍﻧﺘﺨﺎﺏ ﺷﺪﻩ ﺑﻪ 125 ﻣﻘﺎﻟﻪ ﺩﺭ ﻣﺘﻦ ﺍﺳﺘﻨﺎﺩ ﺷﺪﻩ ﺍﺳﺖ. ﺩﺭ ﺍﻧﺘﺨﺎﺏ ﻣﻘﺎﻟﻪ ﻫﺎ ﺑﺮ ﻛﺎﺭﺑﺮﺩﻱ ﺑﻮﺩﻥ ﺁﻧﻬﺎ ﺗﻮﺟﻪ ﺷﺪﻩ ﺍﺳﺖ. ﻳﺎﻓﺘﻪ ﻫﺎ: ﻫﺮ ﭼﻨﺪ ﻛﻪ ﺳﺎﺧﺘﺎﺭ ﻛﻠﻲ ﺑﺮﺧﻮﺭﺩ ﺑﺎ ﺑﻴﻤﺎﺭ ﻣﺒﺘﻼ ﺑﻪ ﺗﻮﻣﻮﺭ ﭘﺴﺘﺎﻥ ﻫﻨﻮﺯ ﺷﺎﻣﻞ ﻣﻌﺎﻳﻨﺔ ﺑﺎﻟﻴﻨﻲ، ﺗﺼﻮﻳﺮ ﺑﺮﺩﺍﺭﻱ ﻭ ﻧﻤﻮﻧﻪ ﮔﻴﺮﻱ ﺍﺳﺖ ﻭﻟﻲ ﺩﺭ ﻳﻚ ﺩﻫﺔ ﺍﺧﻴﺮ ﺩﻳﺪﮔﺎﻩ ﺟﺮﺍﺣﺎﻥ ﻧﺴﺒﺖ ﺑﻪ ﺭﻭﺵ ﺩﺭﻣﺎﻥ ﺳﺮﻃﺎﻥ ﭘﺴﺘﺎﻥ ﺗﻐﻴﻴﺮ ﺍﺳﺎﺳﻲ ﭘﻴﺪﺍ ﻛﺮﺩﻩ ﺍﺳﺖ. ﻧﺘﻴﺠﻪ ﮔﻴـﺮﻱ: ﺑﻪ ﻧﻈﺮ ﻣﻲ ﺭﺳﺪ ﻛﻪ ﺩﺭ ﺁﻳﻨﺪﻩ ﻧﻘﺸﻪ ﮊﻧﺘﻴﻜﻲ ﺑﻴﻤﺎﺭ ﻣﺒﺘﻼ ﺑﻪ ﺗﻮﻣﻮﺭ ﭘﺴﺘﺎﻥ ﺩﺭ ﻃﺮﺍﺣﻲ ﺭﻭﺵ ﺗﺸﺨﻴﺼﻲ ﻭ ﺩﺭﻣﺎﻥ ﻧﻘﺶ ﺍﺳﺎﺳﻲ ﺩﺍﺷﺘﻪ ﺑﺎﺷﺪ.

Introduction & Objective: Systematic classification of huge new information in breast cancer biology and the devising of practical ways of using this information by breast surgeons. Materials & Methods: 1836 articles (from 1986 till 2008) were reviewed of which, 827 were chosen and 125 articles were mentioned. Results: Although the approach to a breast tumor still includes: clinical examination, imaging and sampling, but the attitude towards of it has been basically changed in recent decades. Conclusions: It seems that the gene mapping of such patient will rule an important play on role in the diagnosis and treatment of the breast tumor patients in the future.