ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ ﮔﯿﺎه داروﯾﯽ وﯾﺘﺎﮔﻨﻮس ﺑﺮ ﻋﻼﺋﻢ ﺟﺴﻤﯽ دوران ﯾﺎﺋﺴﮕﯽ

The Effect of Vitex on Somato-Vegetative Symptoms in Menopausal Women

زﻣﯿﻨﻪ و ﻫﺪف: در واﻗﻊ ﯾﺎﺋﺴﮕﯽ ﯾﮏ ﭘﺪﯾﺪه ﺟﻬﺎﻧﯽ ﺑﺮاي زﻧﺎن اﺳﺖ و ﭼﯿﺰي ﺑﯿﻦ 74% ﺗﺎ 80% زﻧﺎن ﺑﺎ ﻋﻼﺋﻢ ﯾﺎﺋﺴﮕﯽ دﺳﺖ و ﭘﻨﺠﻪ ﻧﺮم ﻣﯽﮐﻨﻨﺪ. از ﻋﻼﺋﻤﯽ ﮐﻪ زﻧﺎن در اﯾﻦ دوران ﺗﺠﺮﺑﻪ ﻣﯽﮐﻨﻨﺪ، ﻣﯽﺗﻮان ﺑﻪ ﺗﻌﺮﯾﻖ ﺷﺒﺎﻧﻪ، اﺧﺘﻼﻻت ﺧﻮاب، ﻧﺎراﺣﺘﯽﻫﺎي ﻗﻠﺒﯽ و ﮔﺮﮔﺮﻓﺘﮕﯽ اﺷﺎره ﮐﺮد. درﻣﺎﻧﯽ ﮐﻪ ﻫﻢ اﮐﻨـﻮن ﺑﺮاي ﺑﻬﺒﻮد اﯾﻦ ﻋﻮارض ﺑﻪ ﮐﺎر ﮔﺮﻓﺘﻪ ﻣﯽﺷﻮد، روش ﺟﺎﯾﮕﺰﯾﻦ ﻫﻮرﻣﻮﻧﯽ اﺳﺖ ﮐﻪ ﻋـﻮارض زﯾﺎدي ﺑﻪ دﻧﺒﺎل دارد. ﯾﮑﯽ از ﺟﺎﯾﮕـﺰﯾﻦﻫﺎي ﻫﻮرﻣﻮن درﻣﺎﻧﯽ اﺳﺘﻔﺎده از ﮔﯿﺎﻫﺎﻧﯽ از ﺧﺎﻧﻮاده ﻓﯿﺘﻮ اﺳﺘﺮوژنﻫﺎ، ﻣﺎﻧﻨﺪ وﯾﺘﺎﮔﻨﻮس اﺳﺖ. ﻣﻮاد و روش ﻫﺎ: ﭘﮋوﻫﺶ ﺣﺎﺿﺮ ﯾﮏ ﻣﻄﺎﻟﻌﻪ ﮐﺎرآزﻣﺎﯾﯽ ﺑﺎﻟﯿﻨﯽ دو ﺳﻮ ﮐﻮر ﺑﻮد ﮐﻪ ﺑﺮ روي 100 ﻧﻔﺮ از زﻧﺎن ﯾﺎﺋﺴﻪ اﻧﺠﺎم ﺷﺪه اﺳﺖ. زﻧﺎن ﺷﺮﮐﺖﮐﻨﻨﺪه در اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﻗﺮص ﮔﯿﺎه وﯾﺘﺎﮔﻨﻮس را روزي دو ﺑﺎر ﺑﻪ ﻣﺪت ﯾﮏ ﻣﺎه اﺳﺘﻔﺎده ﮐﺮدﻧﺪ. ﺑﺮاي ﺳﻨﺠﺶ ﻋﻼﺋﻢ ﯾﺎﺋﺴﮕﯽ از ﭘﺮﺳﺸﻨﺎﻣﻪ ﺳﻨﺠﺶ ﻋﻼﺋﻢ ﯾﺎﺋﺴﮕﯽ اﺳﺘﻔﺎده ﺷﺪ. در ﭘﺎﯾﺎن ﯾﮏ ﻣﺎه ﻧﺘﺎﯾﺞ ﺑﺎ اﺳﺘﻔﺎده از ﻧﺮم اﻓﺰار SPSS و آﻣﺎر ﺗﻮﺻﯿﻔﯽ و ﺗﺤﻠﯿﻠﯽ آزﻣﻮنﻫﺎي ﺗﯽ ﺗﺴﺖ و ﺗﮑﺮار ﻣﺸﺎﻫﺪات )Repeatet Measure( ﻣﻮرد ﺗﺠﺰﯾﻪ و ﺗﺤﻠﯿﻞ ﻗﺮار ﮔﺮﻓﺘﻨﺪ. ﯾﺎﻓﺘﻪ ﻫﺎ: ﯾﺎﻓﺘﻪﻫﺎ ﻧﺸﺎن داد اﺳﺘﻔﺎده از وﯾﺘﺎﮔﻨﻮس ﺗﺄﺛﯿﺮ ﺑﺴﺰاﯾﯽ در ﮐﺎﻫﺶ ﮔﺮﮔﺮﻓﺘﮕﯽ )ﻣﯿﺎﻧﮕﯿﻦ و اﻧﺤﺮاف ﻣﻌﯿﺎر ﻗﺒﻞ از ﻣﺪاﺧﻠﻪ 3/222±0/8 و ﻣﯿﺎﻧﮕﯿﻦ و اﻧﺤﺮاف ﻣﻌﯿﺎر ﺑﻌﺪ از ﻣﺪاﺧﻠﻪ 0/8±0/65( و اﺧﺘﻼﻻت ﺧﻮاب )ﻣﯿﺎﻧﮕﯿﻦ و اﻧﺤﺮاف ﻣﻌﯿﺎر ﻗﺒﻞ از ﻣﺪاﺧﻠﻪ 2/562±0/98 و ﻣﯿﺎﻧﮕﯿﻦ و اﻧﺤﺮاف ﻣﻌﯿﺎر ﺑﻌﺪ از ﻣﺪاﺧﻠﻪ 1/05±0/73( در ﮔﺮوه دارو در ﻗﯿﺎس ﺑﺎ داروﻧﻤﺎ داﺷﺘﻪ اﺳﺖ )0/001 < P(. ﻧﺘﯿﺠﻪ ﮔﯿـﺮي: ﻧﺘﺎﯾﺞ ﻧﺸﺎن داد اﺳﺘﻔﺎده از وﯾﺘﺎﮔﻨﻮس درﮐﺎﻫﺶ ﻋﻼﺋﻢ ﺟﺴﻤﯽ در زﻧﺎن ﯾﺎﺋﺴﻪ ﻣﺆﺛﺮ ﺑﻮده و ﻣﯽﺗﻮاﻧﺪ ﺑﻪ ﻋﻨﻮان ﯾﮏ درﻣﺎن ﻣﮑﻤﻞ و ﯾﺎ ﺟﺎﯾﮕﺰﯾﻦ ﻫﻮرﻣﻮﻧﯽ در ﺑﻬﺒﻮد ﻋﻼﺋﻢ ﯾﺎﺋﺴﮕﯽ در زﻧﺎن اﺳﺘﻔﺎده ﺷﻮد.

Introduction & Objective: In fact menopause for women is a global phenomenon and something between 74% and 80% of women with menopausal symptoms struggling up. The symptoms that women experience during this period such as sweating/flush, cardiac complaints, sleeping disorders, joint & muscle complaints and… Now the treatment used for this symptoms are hormone replacement that has the serious effects. One of the alternatives hormone therapy use plants from the family of phytoestrogens, such as the Vitex . Materials & Methods: This study was a double-blind clinical trial that was done on 100 postmenopausal women. Women participating in the study used tab of Vitex twice a day for one month. Menopausal Rating Scale (MRS) questionnaire was used to assess symptoms of menopause. At the end of a month the results using SPSS software and descriptive and analytical statistics (repeated measures test andt-test) were analyzed Results: The findings showed that the use of Vitex effective in decreasing hot flashes and sleep problems complaints compared with the placebo group (P < 0.001). Conclusions: These results suggest that the use of Vitex effective in reducing symptom in women, and can be used as a supplement or hormone replacement therapy used to improve symptoms of menopause in women.