ﺗﺎﺛﯿﺮ ﻋﺼﺎره اﻟﮑﻠﯽ ﮔﻞآذﯾﻦ درﻣﻨﻪ ﺑﺮ روي ﺗﺮﻣﯿﻢ زﺧﻢﻫﺎي دﯾﺎﺑﺘﯽ رتﻫﺎي ﻧﺮ ﻧﮋاد وﯾﺴﺘﺎر

Effects of Alcoholic Extract of Artemisia inflorescence on Wound Healing of Diabetic Wistar Rats

زﺧﻢ ﻫﺎي ﭘﻮﺳﺘﯽ و زﺧﻢ ﭘﺎي دﯾﺎﺑﺘﯽ ﻣﻮﺿﻮﻋﯽ ﻣﻬﻢ در ﻋﻠﻢ ﭘﺰﺷﮑﯽ اﺳﺖ. ﺑﯿﻤﺎري دﯾﺎﺑﺖ ﯾﮑﯽ از ﺷﺎﯾﻊ ﺗﺮﯾﻦ ﺑﯿﻤﺎري ﻫﺎي ﻣﺘﺎﺑﻮﻟﯿﮏ ﻏﺪد درون رﯾﺰ اﺳﺖ. درﻣﻨﻪ داراي اﺛﺮات ﻓﺎرﻣﺎﮐﻮﻟﻮژﯾﮏ ﺑﻪ وﯾﮋه اﺛﺮ ﺑﺮ روي دﯾﺎﺑﺖ اﺳﺖ. ﻫﺪف از اﻧﺠﺎم اﯾﻦ ﻣﻄﺎﻟﻌﻪ، ﻣﻘﺎﯾﺴﻪ اﺛﺮات اﻟﺘﯿﺎم ﺑﺨﺶ ﻋﺼﺎره اﻟﮑﻠﯽ ﮔﯿﺎه درﻣﻨﻪ در ﻓﺮاﯾﻨﺪ ﺗﺮﻣﯿﻢ و ﺳﺮﻋﺖ ﺑﺴﺘﻪ ﺷﺪن زﺧﻢ ﻫﺎي ﭘﻮﺳﺘﯽ در ﻣﻮش ﻫﺎي ﺳﺎﻟﻢ و دﯾﺎﺑﺘﯽ ﻣﯽ ﺑﺎﺷﺪ. ﺑﺮاي اﻧﺠﺎم اﯾﻦ ﺗﺤﻘﯿﻖ، از 20 ﺳﺮ رت ﻧﺮ ﺑﺎﻟﻎ اﺳﺘﻔﺎده ﺷﺪ. رت ﻫﺎ ﺑﻪ ﭼﻬﺎر ﮔﺮوه ﭘﻨﺞ ﺗﺎﯾﯽ ﺗﺤﺖ ﻋﻨﻮان ﮔﺮوه ﮐﻨﺘﺮل، ﺷﻢ، ﺗﺠﺮﺑﯽ1 ﺗﺠﺮﺑﯽ2 ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. ﺳﻪ ﮔﺮوه از رت ﻫﺎ ﺑﺎ اﺳﺘﻔﺎده از اﺳﺘﺮﭘﺘﻮزوﺗﻮﺳﯿﻦ دﯾﺎﺑﺘﯽ ﺷﺪﻧﺪ. در ﻫﻤﻪ ﮔﺮوه ﻫﺎ زﺧﻤﯽ ﺑﻪ ﻃﻮل 2 ﺳﺎﻧﺘﯽ ﻣﺘﺮ ﺑﺮ روي ﭘﻮﺳﺖ ﻧﺎﺣﯿﻪ ﭘﺸﺘﯽ ﺣﯿﻮاﻧﺎت اﯾﺠﺎد ﺷﺪ. روﻧﺪ ﺗﺮﻣﯿﻢ زﺧﻢ ﺑﻪ ﺻﻮرت ﻣﺎﮐﺮوﺳﮑﻮﭘﯽ و ﻣﯿﮑﺮوﺳﮑﻮﭘﯽ ﻣﻮرد ﺑﺮرﺳﯽ ﻗﺮار ﮔﺮﻓﺘﻨﺪ. ﮔﺮوه ﻫﺎي ﺷﻢ و ﺗﺠﺮﺑﯽ1 ﻧﺴﺒﺖ ﺑﻪ ﮔﺮوه ﮐﻨﺘﺮل ﺗﺮﻣﯿﻢ دﯾﺮﺗﺮي داﺷﺘﻪ اﻧﺪ و اﻟﺘﯿﺎم زﺧﻢ در ﮔﺮوه ﺗﺠﺮﺑﯽ2 ﮐﻪ ﺑﺎ ﻋﺼﺎر درﻣﻨﻪ ﮐﻮﻫﯽ ﺗﯿﻤﺎر ﺷﺪ ﻧﺴﺒﺖ ﺑﻪ ﮔﺮوه ﮐﻨﺘﺮل از ﺳﺮﻋﺖ ﺑﯿﺸﺘﺮي ﺑﺮﺧﻮردار ﺑﻮده و ﻣﺴﺎﺣﺖ ﺳﻄﺢ زﺧﻢ ﻧﺴﺒﺖ ﺑﻪ ﺳﺎﯾﺮ ﮔﺮوه ﻫﺎ ﮐﺎﻫﺶ ﯾﺎﻓﺘﻪ اﺳﺖ. ﺑﻪ ﻧﻈﺮ ﻣﯽ رﺳﺪ اﺳﺘﻌﻤﺎل ﻣﻮﺿﻌﯽ ﻋﺼﺎره درﻣﻨﻪ ﻣﻮﺟﺐ ﺗﺴﺮﯾﻊ ﺑﻬﺒﻮدي زﺧﻢ در رت ﻫﺎي دﯾﺎﺑﺘﯽ ﻣﯽ ﺷﻮد و ﻣﻮاد ﺟﻮد در درﻣﻨﻪ ﻣﻮﺟﺐ، اﻧﻘﺒﺎض ﺳﺮﯾﻊ ﺗﺮ زﺧﻢ و اﻟﺘﯿﺎم زﺧﻢ ﻣﯽ ﺷﻮد.

Skin ulcers and diabetic foot ulcers are an important issue in medicine. Diabetes is one of the most common metabolic diseases of the endocrine system. Artemisia pharmacological, particularly effects on diabetes. The aim of this study was to compare the healing effects of alcoholic extract of Artemisia in the process of healing and skin wounds in normal and diabetic rats is quickly closing. Overall, 20 adult male Wistar rats were used. The rats were divided into four groups of five controls (without diabetes and treatment), sham (diabetes treatment Eucerin), Experimental 1 (diabetes without treatment), Experimental 2 (diabetes treated with alcoholic extract of Artemisia) were divided. Three groups of rats were made diabetic using STZ. Over 2 cm wound on the skin of spinous were created in all groups. The experimental group and the experimental group 2 with wormwood extract 1 Eucerin day with a dose of 100 mg Barba topical treatment over a period of 21 d, respectively. Wound healing was evaluated by macroscopic and microscopic. Wound healing in experimental groups 1 and 2 was treated with than the alcoholic extract of Artemisia control group showed the highest rate. Wormwood extract leads to topical wound healing in diabetic rats and material contained in Artemisia cause, faster wound contraction, and the healing.