زمينه مطالعه: در سالهاي اخير، اختلال در متابوليسم ليپيدها، به شكل قابل توجهي، در جمعيت حيوانات خانگي افزايش يافته است. هيپرليپيدمي، يك علامت شايع از بروز چاقي در سگها است كه بهصورت هيپركلسترولمي يا هيپرتريگليسريدمي مشخص ميگردد. هدف: هدف از انجام تحقيق حاضر، تعيين اثر چاقي بر تغييرات پروفايلهاي ليپيدي خون (مشتمل بر تريگليسريد، كلسترول تام، HDL-C و LDL-C) و مقايسه شاخصهاي تعيين كنننده چاقي در سگهاي منطقه اهواز ميباشد. روش كار: 3 گروه 30 تايي از سگهاي ارجاعي به بيمارستان دامپزشكي اهواز، در طول سالهاي 93-1391 مورد مطالعه قرار گرفتند. سگهاي گروه A (كنترل)، از وضعيت بدني خوبي (4 تا 5= BCS) برخوردار بودند. سگهاي گروه B، همگي لاغر (1 تا 3= BCS) و گروه C، چاق (6 تا 9= BCS) بودند. تمامي سگهاي مورد مطالعه، از نژاد كوچك (ترير، اشپيتز، پكينز و شيتزو)، از هر دو جنس و در محدوده سني 1 تا 7 سال انتخاب شدند. خونگيري ناشتا از تمام سگها، اخذ شده و پروفايلهاي ليپيدي مشتمل بر تريگليسريد، كلسترول تام، HDL-C و LDL-C سرم با كيتهاي تجاري معمول اندازهگيري شدند. نتايج: هيپرليپيدمي در سگهاي گروه A (نرمال) در 4 مورد (33/13 درصد)، گروه B (لاغر) 1 مورد (33/3 ٪) و گروه C (چاق) در 19 مورد (33/63 ٪) تاييد گرديد. تحليل آماري دادهها نشان داد كه از نظر ميزان تريگليسريد، بين گروه C (34/74±83/224) با گروههاي A (66/39±149) و B (37/24±80/131) تفاوت معنيدار وجود داشت (001/0>p). از نظر كلسترول، بين گروه C (36/60±40/229) با گروههاي A (17/50±80/178) و B (45/23±47/151) (001/0>p) و نيز گروه A با B تفاوت معنيدار مشاهده گرديد (05/0>p). از نظر LDL-C، بين گروه C (83/22±10/67) با گروههاي A (01/13±97/47) و B (08/13±07/43) تفاوت معنيدار وجود داشت (001/0>p)، اما از نظر HDL-C، تفاوت بين گروههاي مختلف ديده نشد (05/0
چكيده لاتين :
BACKGROUND: In recent years, disorder in lipid metabolism has been increased markedly in companion animal’s population. Hyperlipidemia is a common sign of obesity in dogs, which is characterized by hypercholesterolemia or hypertriglycemia. OBJECTIVES: The purpose of the present survey is to determine the effect of obesity on blood lipid profile changes (including triglyceride, total cholesterol, HDL-C and LDL-C) and comparing the decisive indicators of obesity in dogs in Ahvaz district. METHODS: Three groups of thirty dogs referred to Veterinary Hospital of Ahvaz were studied between 2012-2014. The dogs in group A (control), had good body condition score (BCS= 4 to 5). The dogs were all thin (BCS= 1 to 3) in group B, and all obese in group C (BCS= 6 to 9). All of the studied dogs were selected from small breeds (Terrier, Spitz, Pekingese and Shih Tzu), of both sexes and ranging from 1 to 7 years old. Fasting blood samples were collected from all dogs and lipid profiles including serum triglycerides, total cholesterol, HDL and LDL were measured using commercial kits. RESULTS: Hyperlipidemia was confirmed in dogs of group A (normal) in 4 cases (13.33%), group B (thin) one case (3.33%), and group C (obese) in 19 cases (63.33%). Data analysis showed that there was a significant difference between group C (224.83±74.34) with groups A (149±39.66) and B (131.80±24.37) for triglyceride level (p<0.001), as well a significant difference was seen between group C (229.40±60.36) with groups A (178.80±50.17) and B (151.47±23.45) and between group A with B for cholesterol level (p<0.05). The difference was significant for LDL-C between group C (67.10±22.83) with groups A (47.97±13.01) and B (43.07±13.08) (p<0.001), but there was no difference between various groups for HDL-C (p>0.05). The effects of age, gender and breed on the measured values did not show a significant difference between three groups (p>0.05). CONCLUSIONS: The present survey showed that there was a correlation between obesity and hyperlipidemia in dogs. Determination of body condition score (BCS) can be as a predictive agent in characterization of lipid profile status. Modification of diet and weight loss is necessary in obese dogs.