ارتباط بين سطوح سرمي سيستاتين C با جريان آهسته كرونري و شاخص توده بدن در ‌مردان

Correlation between serum levels of cystatin C and coronary slow flow and body mass index in men

زمينه و هدف: سيستاتين C به‌عنوان يك مهاركننده‌ي پروتئاز سيستيين توسط تمامي سلول‌هاي هسته‌دار در يك سطح ثابت ترشح و توليد مي‌شود. هدف از پژوهش كنوني بررسي ارتباط بين سطوح سرمي سيستاتين C با پديده‌ي جريان آهسته كرونري و شاخص توده‌ي بدن در مردان بود. روش بررسي: پژوهش توصيفي-تحليلي كنوني بر روي بيماران مرد 34 تا 73 سال مراجعه‌كننده به بيمارستان سيدالشهدا اروميه از فروردين 1394 تا اسفند 1395 كه به هر علتي براي نخستين بار تحت آنژيوگرافي تشخيصي عروق كرونري قرار گرفته بودند، انجام پذيرفت. 74 بيمار مرد تحت آنژيوگرافي تشخيصي عروق كرونري به‌عنوان نمونه انتخاب شده و به‌طور داوطلبانه در اين پژوهش شركت نمودند. ويژگي‌هاي دموگرافيك شامل سن، قد، وزن، شاخص توده‌ي بدن تمامي بيماران گردآوري و ثبت شد. بيماران با سيستم آنژيوگرافي متحرك از نظر جريان خون كرونري بررسي شدند كه به‌صورت كمي و با شمارش چارچوب تصحيح‌شده‌ي ترومبوليز در انفاركتوس ميوكارد انجام شد. سطوح سرمي سيستاتين C با دستگاه الايزا از نمونه‌هاي خوني حاصل از وريد بازويي اندازه‌گيري شد. يافته‌ها: ميانگين متغيرهاي دموگرافيك و فيزيولوژيك آزمودني‌ها عبارتند از سن 9/00±54/77 سال، قد cm 0/12±1/74، وزن kg 6/85±73/13 و شاخص توده‌ي بدن kg/m2 3/83±26/98. همچنين نتايج اين پژوهش نشان داد كه بين سطوح سرمي سيستاتين C با جريان آهسته‌ي كرونري و شاخص توده‌ي بدن رابطه معناداري وجود نداشت (به‌ترتيب 0/871=P و 0/494=P). نتيجه‌گيري: نتايج اين پژوهش بيانگر آن است كه سطوح سرمي سيستاتين C با پديده‌ي جريان آهسته كرونري و شاخص توده‌ي بدن در بيماران مرد كانديد آنژيوگرافي 34 تا 73 سال ارتباط معناداري نداشت.

Background: Cystatin C (Cys C) as a cysteine protease inhibitor is produced in a constant level from all nucleated cells. The purpose of this study was to investigate the correlation between serum levels of Cys C and coronary slow flow (CSF) and body mass index (BMI) in men. Methods: This investigation is in the form of a descriptive-analytical study. The statistical population was all non-active male aged 34-73 years with CSF candidate for angiography referring to Seyedoshohada University Hospital, Urmia, Iran, from March 2015 to February 2017. After obtaining an inform consent, 74 male patients (mean age 54.77±9.00 years, height 1.74±0.12 cm, weight 73.13±6.85 kg, and BMI 26.98±3.83 kg/m2) were selected by convenience non-random sampling as the sample size (patients were eligible for diagnostic coronary artery angiography for the first time and referring to Seyedoshohada University Hospital in Urmia). Then all the patients were placed under angiography with one mobile angiography system. Patients were assessed for coronary blood flow with a quantitative method using corrected thrombolysis frame count in myocardial infarction (CTFC). All the patients with TFC larger than two standard deviation pre-published area for a specific vessel were counted as CSF. Demographic characteristics of age, height, weight, and BMI in male patients were measured by wall-meter with an accuracy of one millimeter, digital scale with precision of 100 g, and weight/hieght2 formula, respectively. The traditional risk factors including smoking, diabetes mellitus (DM), high blood pressure (HBP), dyslipidemia, and family history were also assessed using a checklist. Serum levels of Cys C were measured by ELISA machine. Results: The mean demographic and physiological variables of subjects were: age 54.77±9.00 yr, height 1.74±0.12 cm, weight 73.13±6.85 kg, and BMI 26.98±3.83 kg/m2. Also, the results of this study showed that there were no significant correlations between serum levels of Cys C with CSF and BMI in male patients’ candidate for angiography referring to Seyedoshohada University Hospital (P=0.871 and P=0.494, respectively). Conclusion: The results of this study suggest that serum levels of Cys C had no significant correlations with the CSF and BMI in male patients’ candidate for angiography aged 34-73 years.