Synthesis, Characterization, Antibacterial properties and DNA Binding of a Th(IV) Complex

In this investigation, we have reported the synthesis of the complex [Th(5,5´dmbpy)3](NO3)4](1) that 5,5´dmbpy =5,5´dimethyl2,2´bipyridine. This complex has been characterized using spectral methods (FTIR, UVVis, 1HNMR and luminescence), elemental analysis and the Cyclic Voltammetry (CV) method. The FTIR data shows that 5,5´dimethyl2,2´bipyridine (5, 5´ dmbpy) ligand adduct to metal centers by nitrogen atoms. Electronic spectra of (1) shows ligand field transitions and charge transfer (CT) bands. Electrochemical data for the complex in the DMF solution show reduction and oxidation processes for the Thorium ion and ligand. The interactions of complex (1) with FSDNA have been investigated using UV–Vis and gel electrophoresis. The binding constant (Kb) was calculated using UV–Vis technique (Kb=3.5×105). Also, DNA cleavage was studied using agarose gel electrophoresis. The antibacterial properties and fluorescence property of complex (1) have also been examined. The in vitro biological screening effects of the complex and ligand were tested against different types of bacterium and [Th(5,5´dmbpy)3](NO3)4](1) shows antibacterial properties.