اﺛﺮ ﯾﮏ دوره12 ﻫﻔﺘﻪاي ﺗﻤﺮﯾﻦ ﺗﺮﮐﯿﺒﯽ ﺑﺮ ﺳﻄﻮح BDNF، ﻋﻮاﻣﻞ ﻫﻤﺎﺗﻮﻟﻮژﯾﮏ و ﺑﺮﺧﯽ از ﺷﺎﺧﺺ ﻫﺎي ﺳﯿﺴﺘﻢ اﯾﻤﻨﯽ در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﻣﺎﻟﺘﯿﭙﻞ اﺳﮑﻠﺮوزﯾﺲ

The Effect of A 12-Week Resistance and Endurance Training on The Serum Levels BDNF, Hematological Factors and Some Immune System Indices in Women With Multiple Sclerosis

زﻣﯿﻨﻪ و ﻫﺪف: ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ اﺛﺮات ﻣﺜﺒﺖ ﻓﻌﺎﻟﯿﺖ ورزﺷﯽ در ﺑﯿﻤﺎران MS و ﺗﺎﺛﯿﺮي ﮐﻪ ﺑﺮ ﻋﻨﺎﺻﺮ و اﺟﺰاي ﻣﺨﺘﻠﻒ ﺳﯿﺴﺘﻢ اﯾﻤﻨﯽ دارد و ﮐﻤﺒﻮد اﻃﻼﻋﺎت در زﻣﯿﻨﻪ ﺗﻤﺮﯾﻨﺎت ﺗﺮﮐﯿﺒﯽ، ﻫﺪف ﺗﺤﻘﯿﻖ ﺣﺎﺿﺮ ﺑﺮرﺳﯽ اﺛﺮ ﯾﮏ دوره 12 ﻫﻔﺘﻪاي ﺗﻤﺮﯾﻦ ﺗﺮﮐﯿﺒﯽ ﺑﺮ ﺳﻄﻮح BDNF، ﻋﻮاﻣﻞ ﻫﻤﺎﺗﻮﻟﻮژﯾﮏ و ﺑﺮﺧﯽ از ﺷﺎﺧﺺ ﻫﺎي ﺳﯿﺴﺘﻢ اﯾﻤﻨﯽ در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﻣﺎﻟﺘﯿﭙﻞ اﺳﮑﻠﺮوزﯾﺲ ﺑﻮد.. ﻣﻮاد و روش ﻫﺎ: ﺑﻪ اﯾﻦ ﻣﻨﻈﻮر، ﺗﻌﺪاد 24 زن ﻣﺒﺘﻼ ﺑﻪ ﻣﻮﻟﺘﯿﭙﻞ اﺳﮑﻠﺮوزﯾﺲ 20 ﺗﺎ50 ﺳﺎﻟﻪ ﺑﺎ درﺟﻪ ﻧﺎﺗﻮاﻧﯽ)EDSS( ﺑﯿﻦ 2 ﺗﺎ 5 ﺑﻪ ﺻﻮرت ﺗﺼﺎدﻓﯽ در دو ﮔﺮوه ﮔﻮاه)12 ﻧﻔﺮ( و آزﻣﺎﯾﺶ)12 ﻧﻔﺮ( ﻗﺮار ﮔﺮﻓﺘﻨﺪ. ﺑﺮﻧﺎﻣﻪ ﺗﻤﺮﯾﻦ ﺷﺎﻣﻞ12 ﻫﻔﺘﻪ و 3ﺟﻠﺴﻪ در ﻫﻔﺘﻪ) دو ﺟﻠﺴﻪ ﺗﻤﺮﯾﻦ ﻫﻮازي و ﯾﮏ ﺟﻠﺴﻪ ﺗﻤﺮﯾﻦ ﻣﻘﺎوﻣﺘﯽ( ﺑﻮد. ﯾﺎﻓﺘﻪ ﻫﺎ: ﯾﺎﻓﺘﻪﻫﺎ ﻧﺸﺎن داد ﮐﻪ در ﮔﺮوه ﺗﻤﺮﯾﻨﯽ ﻣﯿﺰان ﻟﻨﻔﻮﺳﯿﺖ ﻫﺎ)0001/ 0=p (، ﻣﻨﻮﺳﯿﺖ ﻫﺎ)0001/ 0=p ( و ﻧﻮﺗﺮوﻓﯿﻞ ﻫﺎ)003/ 0=p ( ﺑﻪ ﻃﻮر ﻣﻌﻨﺎداري اﻓﺰاﯾﺶ ﯾﺎﻓﺘﻨﺪ، اﻣﺎ ﺗﻐﯿﯿﺮ ﻣﻌﻨﯽداري در ﺷﻤﺎر ﭘﻼﮐﺖ ﻫﺎ)11/ 0=p (، ﻣﯿﺰان ﮔﻠﺒﻮل ﻫﺎي ﻗﺮﻣﺰ)34/ 0=p (، ﻫﻤﺎﺗﻮﮐﺮﯾﺖ)08/ 0=p ( و p=0 /10) BDNF ( ﻣﺸﺎﻫﺪه ﻧﺸﺪ. ﻫﻤﭽﻨﯿﻦ در ﮔﺮوه ﮔﻮاه ﻧﯿﺰ ﻫﯿﭻﮔﻮﻧﻪ ﺗﻐﯿﯿﺮ ﻣﻌﻨﯽداري دﯾﺪه ﻧﺸﺪ. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: ﺑﻪ ﻃﻮر ﮐﻠﯽ ﻣﯽﺗﻮان ﮔﻔﺖ ﮐﻪ اﻧﺠﺎم ﺑﺮﻧﺎﻣﻪﻫﺎي ﺗﻤﺮﯾﻦ ﺗﺮﮐﯿﺒﯽ ﺷﺎﻣﻞ وﻫﻠﻪﻫﺎي ﻓﻌﺎﻟﯿﺖ ﻫﻮازي و ﻣﻘﺎوﻣﺘﯽ در 3 روز ﻏﯿﺮ ﻣﺘﻮاﻟﯽ در ﻫﻔﺘﻪ، ﺑﺮاي زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ MS ﺳﻮدﻣﻨﺪ ﺑﻮده و ﭘﯿﺸﻨﻬﺎد ﻣﯽﮔﺮدد. اﻣﺎ ﺑﻪ ﻧﻈﺮ ﻣﯽ رﺳﺪ ﮐﻪ ﺑﺮاي اﺛﺮ ﮔﺬاري ﺑﯿﺸﺘﺮ ﺗﻤﺮﯾﻦ، ﺑﻪ وﯾﮋه ﺑﺮ ﺷﺎﺧﺺ ﻫﺎي ﻫﻤﺎﺗﻮﻟﻮژﯾﮏ و ﻧﻮروﺗﺮوﻓﯿﮏ، ﺑﻬﺘﺮ اﺳﺖ ﺑﺎر ﺗﻤﺮﯾﻨﺎت، ﺑﯿﺸﺘﺮ در ﻧﻈﺮ ﮔﺮﻓﺘﻪ ﺷﻮد.

Background and Purpose: Considering the positive effects of exercise in multiple sclerosis patients and the effect on the elements and components of the immune system and the lack of information in the field of combined training, The purpose of the present study was to investigate the effect of 12-week resistance and endurance training program on the serum levels BDNF, hematological factors and some immune system indices in women with multiple sclerosis Methodology: Twenty four 20-to-50-year-old women with multiple sclerosis and a disability level of 2-5 as measured by EDSS (Expanded Disability Status Scale) were randomly assigned to two groups of control (12 patients) and experimental (12 patients). The participants received exercise training three sessions a week for 12 weeks (two sessions of aerobic training and one session of resistance training). Results: The results showed a significant increase in Lymphocytes (p=0.0001), Monocytes (p=0.0001) and Neutrophils (p=0.003) in the experimental group but there was no significant change in the number of platelets (p = 0.19), red blood cells (p=0.34), hematocrit (p=0.08) and BDNF (p=0.10). Also no significant changes was observed in the control group. Conclusions: The combined exercise training, including aerobic and resistance training, in three non-consecutive days per week is helpful for women with MS. However, it seems that a more intensive exercise training is more effective