ﺗﺎﺛﯿﺮ ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﺮ ﻓﻌﺎﻟﯿﺖ آﻧﺰﯾﻢﻫﺎي اﺳﺘﯿﻞﮐﻮﻟﯿﻦاﺳﺘﺮاز و ﺑﻮﺗﺮﯾﻞﮐﻮﻟﯿﻦاﺳﺘﺮاز ﺳﺮم و ﺗﻐﯿﯿﺮات ﺷﺎﺧﺺﻫﺎي ﺧﻄﺮ ﻗﻠﺒﯽ-ﻣﺘﺎﺑﻮﻟﯿﮑﯽ زﻧﺎن ﻣﯿﺎﻧﺴﺎل

The Effects of Aerobic Training on Blood ACHE and BCHE Activities and cardiometabolic Risk Factors Level in Midlife Women

ﻣﻘﺪﻣﻪ و ﻫﺪف: ﻣﻌﻤﻮﻻ در وﺿﻌﯿﺖ ﺳﻨﺪرمﻣﺘﺎﺑﻮﻟﯿﮏ، ﯾﮏ ﺣﺎﻟﺖ اﻟﺘﻬﺎﺑﯽ ﻣﺰﻣﻦ درﺟﻪ ﭘﺎﯾﯿﻦ ﺣﺎﮐﻢ اﺳﺖ ﮐﻪ ﺑﻪ ﻋﻠﺖ ﻣﺘﻤﺮﮐﺰﺷﺪن ﺑﻪ اﻧﺪامﻫﺎي داﺧﻠﯽ ﺗﺸﺨﯿﺺ آن دﺷﻮار اﺳﺖ. وﻟﯽ اﻓﺰاﯾﺶ ﻓﻌﺎﻟﯿﺖﻫﺎي اﺳﺘﯿﻞﮐﻮﻟﯿﻦاﺳﺘﺮاز)ACHE(، ﺑﻮﺗﺮﯾﻞﮐﻮﻟﯿﻦاﺳﺘﺮاز)BCHE( ﻋﻼوه ﺑﺮ اﯾﻨﮑﻪ ﻧﺸﺎﻧﮕﺮ ﻗﺎﺑﻞاﻋﺘﻤﺎد اﯾﻦ ﻧﻮع اﻟﺘﻬﺎب ﻫﺴﺘﻨﺪ، ﻫﻤﭽﻨﯿﻦ ﺑﻪﻋﻨﻮان ﺷﺎﺧﺺ زودﻫﻨﮕﺎم ﺳﻨﺪرمﻣﺘﺎﺑﻮﻟﯿﮏ ﻧﯿﺰ ﺷﻨﺎﺧﺘﻪ ﺷﺪهاﻧﺪ. ﺑﻨﺎﺑﺮاﯾﻦ ﻫﺪف ﻣﺎ ﺑﺮرﺳﯽ ﺗﺎﺛﯿﺮ ﺗﻤﺮﯾﻦﻫﻮازي ﺑﺮ ﻓﻌﺎﻟﯿﺖ ACHE و BCHE ﺳﺮﻣﯽ و ﺷﺎﺧﺺﻫﺎي ﺧﻄﺮ ﻗﻠﺒﯽ-ﻣﺘﺎﺑﻮﻟﯿﮏ در زﻧﺎن ﻣﯿﺎﻧﺴﺎل ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرمﻣﺘﺎﺑﻮﻟﯿﮏ ﯾﻮد. روشﺷﻨﺎﺳﯽ: ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ از ﻧﻮع ﺗﺠﺮﺑﯽ ﺑﻮد ﮐﻪ در آن 25 (65-40 ﺳﺎل) زن ﭼﺎق ﻏﯿﺮﻓﻌﺎل داوﻃﻠﺐ داراي ﺣﺪاﻗﻞ ﺳﻪ ﺷﺎﺧﺺ ﺧﻄﺮ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ ﺑﻪ ﻃﻮر ﺗﺼﺎدﻓﯽ در دو ﮔﺮوه ﺗﺠﺮﺑﯽ (13) و ﮐﻨﺘﺮل (12) ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. ﮔﺮوه ﺗﺠﺮﺑﯽ ﺑﻪ ﻣﺪت ﻫﺸﺖ ﻫﻔﺘﻪ در ﺑﺮﻧﺎﻣﻪ ﺗﻤﺮﯾﻦ ﻫﻮازي ﺷﺎﻣﻞ راه رﻓﺘﻦ و دوﯾﺪن (3 ﺑﺎر درﻫﻔﺘﻪ)، ﺑﻪ ﻣﺪت 40دﻗﯿﻘﻪ در ﻫﺮ ﺟﻠﺴﻪ ﺑﺎ ﺷﺪت 60 ﺗﺎ70 درﺻﺪ از ﺿﺮﺑﺎن ﻗﻠﺐ ذﺧﯿﺮه ﺷﺮﮐﺖ ﮐﺮدﻧﺪ. ﻣﻘﺪار BCHE ،ACHE ﺳﺮم و ﺳﻄﻮح ﺷﺎﺧﺺﻫﺎي ﺧﻄﺮ ﻣﺘﺎﺑﻮﻟﯿﮏ در ﻃﻮل ﻣﺪاﺧﻠﻪ ﺑﺎ اﺳﺘﻔﺎده از آزﻣﻮن ﺗﯽ ﻫﻤﺒﺴﺘﻪ ﺑﻪ ﻃﻮر درونﮔﺮوﻫﯽ ﻣﻘﺎﯾﺴﻪ ﺷﺪﻧﺪ. ﯾﺎﻓﺘﻪﻫﺎ: در ﻃﻮل ﻣﺪاﺧﻠﻪ، ﺗﻔﺎوت ﻣﻌﻨﯽداري در ﻣﺘﻐﯿﺮﻫﺎي ﮔﺮوه ﮐﻨﺘﺮل ﻣﺸﺎﻫﺪه ﻧﺸﺪ)0/05>P(. ﺑﻪدﻧﺒﺎل ﺗﻤﺮﯾﻦ ﻫﻮازي، ﻣﻘﺪار ﻟﯿﭙﻮﭘﺮوﺗﺌﯿﻦ ﭘﺮﭼﮕﺎل اﻓﺰاﯾﺶ(P=0/001) و ﻣﻘﺪار P=0/008) BCHE)، ﮔﻠﻮﮐﺰ ﺧﻮن(P=0/0001)، دور ﮐﻤﺮ(0/0001=P) و اﻣﺘﯿﺎز z ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ(0/001=P) ﮐﺎﻫﺶ ﯾﺎﻓﺘﻨﺪ. وﻟﯽ P=0/34) ACHE)، ﺗﺮيﮔﻠﯿﺴﺮﯾﺪ(P=0/052)، ﻓﺸﺎرﺧﻮن ﻣﺘﻮﺳﻂ ﺳﺮﺧﺮﮔﯽ(P=0/15)، ﺗﻌﺪاد ﻋﺎﻣﻞﻫﺎي ﺧﻄﺮ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ(P=0/054)، ﭘﺲ از ﺗﻤﺮﯾﻦ ﺗﻐﯿﯿﺮ ﻣﻌﻨﯽداري ﻧﺪاﺷﺘﻨﺪ. ﻧﺘﯿﺠﻪﮔﯿﺮي: ﺗﻤﺮﯾﻦ ﻫﻮازي ﻋﻼوه ﺑﺮ ﮐﺎﻫﺶ وﺧﺎﻣﺖ ﮐﻠﯽ ﺳﻨﺪرمﻣﺘﺎﺑﻮﻟﯿﮏ، ﺑﻪ ﻃﻮر ﻫﻤﺰﻣﺎن ﺷﺪت اﻟﺘﻬﺎب ﺳﯿﺴﺘﻤﯿﮏ را ﻧﯿﺰ ﮐﺎﻫﺶ ﻣﯽدﻫﺪ ﮐﻪ ﺗﺼﻮر ﻣﯽﺷﻮد در ﺟﻠﻮﮔﯿﺮي از ﻋﻮاﻗﺐ ﻧﺎﻣﻄﻠﻮب ﺳﻨﺪرمﻣﺘﺎﺑﻮﻟﯿﮏ ﺑﺴﯿﺎر ﻣﻮﺛﺮ ﺑﺎﺷﺪ. وﻟﯽ ﺑﻪ ﻧﻈﺮ ﻣﯽ رﺳﺪ ﮐﻪ ﺗﻔﺴﯿﺮ دﻗﯿﻖ ﻧﺘﺎﯾﺞ ACHE ﻧﯿﺎزﻣﻨﺪ ﺑﺮرﺳﯽ ﮔﻠﺒﻮﻟﻬﺎي ﻗﺮﻣﺰ ﺑﻪ ﺟﺎي ﺳﺮم در ﺗﺤﻘﯿﻘﺎت آﯾﻨﺪه اﺳﺖ

Background&Purpose: There is a low grade inflammatory state in patients with metabolic syndrome (Mets) with internalization into deeper body organs which had made its diagnosis even more difficult. However, the activities of ACHE and BCHE were found as early indicators of Mets in addition to be as reliable markers of such inflammation. Therefore, we investigated the effects of aerobic training on serum ACHE and BCHE activities and cardiometabolic risk factors in middle aged women with Mets. Methodology: The present study was an experimental study in which 25 volunteers (aged 40-65) who were volunteered for obesity with at least three indicators of metabolic syndrome were screened and randomly divided into experimental and control groups (12). The experimental group participated in the aerobic exercise program for walking and running (3 times a week) for 40 minutes and for 60 to 70 percent of maximum heart rate for 40 minutes. Data were analyzed by using t-test to compare the amount of acetylcholinesterase, butylcolinasease and metabolic syndrome indices between pre-test and post-test. Results: Following to aerobic training, the plasma HDL (P=0.001) were increased and the serum BCHE activity (P=0.008), blood sugar (P=0.001), waist circumference (P=0.001) and Mets Z score (P=0.001) were decreased in the AT group. Conclusion: After the aerobic exercise, the values of the boolean polysaccharide (p = 0.008), the high density lipoprotein (p = 0.001), the blood glucose (p = 0.0001), and the waist circumference (p = 0.0001) and the z score of the metabolic syndrome (p = 0.001) differed substantially. However, acetylcholinesterase (P = 0.34), triglyceride (p = 0.052), arterial blood pressure (p = 0.15), number of risk factors of metabolic syndrome (p = 0.054), after exercise were not significantly decreased.