ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ ﯾﮏ دوره ﺗﻤﺮﯾﻦ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ ﻫﻤﺮاه ﺑﺎ ﻣﺼﺮف ﻣﮑﻤﻞ دارﭼﯿﻦ ﺑﺮ ﻏﻠﻈﺖ ﺳﺮﻣﯽ DPP4، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ، ﺗﺮﮐﯿﺐ ﺑﺪﻧﯽ و Vo2max ﭘﺴﺮان داراي اﺿﺎﻓﻪوزن

The Effect of HIIT with Supplementation of Cinnamon on DPP4 Concentration, Insulin Resistance, BMI and Vo2max in Overweight Boys

ﺳﺎﺑﻘﻪ و ﻫﺪف: دي ﭘﭙﺘﯿﺪﯾﻞ ﭘﭙﺘﯿﺪاز (DPP4) ﯾﮏ آدﯾﭙﻮﮐﺎﯾﻦ ﻣﺮﺗﺒﻂ ﺑﺎ ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ اﺳﺖ. ﻣﻬﺎر آن ﻣﻮﺟﺐ اﻓﺰاﯾﺶ ﺗﻮاﻧﺎﯾﯽ ﺑﺪن در ﮐﻨﺘﺮل ﻗﻨﺪﺧﻮن و اﻓﺰاﯾﺶ اﮐﺴﯿﺪاﺳﯿﻮن ﭼﺮﺑﯽ ﻣﯽﺷﻮد. از ﺳﻮي دﯾﮕﺮ، دارﭼﯿﻦ ﺑﻪ وﺳﯿﻠﻪ ﻓﻌﺎل ﮐﺮدن ﮔﯿﺮﻧﺪه اﻧﺴﻮﻟﯿﻨﯽ ﺑﺎﻋﺚ اﻓﺰاﯾﺶ ﺑﺮداﺷﺖ ﮔﻠﻮﮐﺰ ﻣﯽﺷﻮد. ﺑﻨﺎﺑﺮاﯾﻦ ﻫﺪف اﯾﻦ ﭘﮋوﻫﺶ ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ ﯾﮏ دوره ﺗﻤﺮﯾﻦ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ (HIIT) ﻫﻤﺮاه ﺑﺎ ﻣﺼﺮف ﻣﮑﻤﻞ دارﭼﯿﻦ ﺑﺮ ﻏﻠﻈﺖ DPP4، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ، ﺗﺮﮐﯿﺐ ﺑﺪﻧﯽ و اﮐﺴﯿﮋن ﻣﺼﺮﻓﯽ ﺑﯿﺸﯿﻨﻪ (Vo2max) در ﭘﺴﺮان داراي اﺿﺎﻓﻪوزن ﺑﻮد. ﮐﯿﻠﻮﮔﺮم 29-25 BMI ﮐﯿﻠﻮﮔﺮم و51-61 ﺳﺎﻧﺘﯿﻤﺘﺮ، وزن 162-172 ﺳﺎل، ﻗﺪ 16-18ﻣﻮاد و روشﻫﺎ: آزﻣﻮدﻧﯽﻫﺎي ﭘﮋوﻫﺶ (داﻣﻨﻪ ﺳﻨﯽ ﺑﺮ ﻣﺘﺮ ﻣﺮﺑﻊ) ﺑﻪﻃﻮر ﻫﺪﻓﻤﻨﺪ اﻧﺘﺨﺎب ﺷﺪه و ﺑﻪﺻﻮرت ﺗﺼﺎدﻓﯽ در ﭼﻬﺎر ﮔﺮوه ﺗﻤﺮﯾﻦ، ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ، ﻣﮑﻤﻞ و ﮐﻨﺘﺮل ﻗﺮار ﮔﺮﻓﺘﻨﺪ. ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ و ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ ﺑﻪ ﻣﺪت ﺷﺶ ﻫﻔﺘﻪ و ﺳﻪ ﺟﻠﺴﻪ در ﻫﻔﺘﻪHIIT اﻧﺠﺎم دادﻧﺪ. ﻫﺮ ﺟﻠﺴﻪ ﺗﻤﺮﯾﻨﯽ ﺷﺎﻣﻞ ﺳﻪ وﻫﻠﻪHIIT (ﭼﻬﺎر دﻗﯿﻘﻪ ﺑﺎ ﺷﺪت 90% ﺿﺮﺑﺎن ﻗﻠﺐ ذﺧﯿﺮه) ﺑﺎ دو دﻗﯿﻘﻪ اﺳﺘﺮاﺣﺖ ﺑﯿﻦ ﻫﺮ دو وﻫﻠﻪ ﺑﻮد و ﺗﺎ ﻫﻔﺘﻪ ﭼﻬﺎرم ﻫﺮ ﻫﻔﺘﻪ ﯾﮏ وﻫﻠﻪ ﺑﻪ ﺗﻌﺪاد وﻫﻠﻪﻫﺎ اﺿﺎﻓﻪ ﺷﺪ. آزﻣﻮدﻧﯽﻫﺎي ﮔﺮوهﻫﺎي ﻣﮑﻤﻞ و ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ، روزاﻧﻪ ﺳﻪ ﮐﭙﺴﻮل ﺣﺎوي 380 ﻣﯿﻠﯽﮔﺮم دارﭼﯿﻦ ﻣﺼﺮف ﻣﯽﮐﺮدﻧﺪ. ﻣﻘﺎدﯾﺮ DPP4، ﻣﻘﺎوﻣﺖ اﻧﺴﻮﻟﯿﻨﯽ، اﻧﺴﻮﻟﯿﻦ، ﮔﻠﻮﮐﺰ ﻧﺎﺷﺘﺎ، درﺻﺪ ﭼﺮﺑﯽ، BMI و Vo2max، 48 ﺳﺎﻋﺖ ﭘﯿﺶ و ﭘﺲ از ﺑﺮﻧﺎﻣﻪ ﺗﻤﺮﯾﻨﯽ ارزﯾﺎﺑﯽ ﺷﺪ. ﺑﺮاي ﺗﺤﻠﯿﻞﻫﺎي آﻣﺎري از آزﻣﻮن ﺗﺤﻠﯿﻞ وارﯾﺎﻧﺲ دوﻃﺮﻓﻪ اﺳﺘﻔﺎده ﺷﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﮐﺎﻫﺶ ﻣﻌﻨﯽداري در ﺳﻄﻮح DPP4 ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ (0/001=P) و ﺗﻤﺮﯾﻦ (0/004=P)، ﻣﯿﺰان ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ (0/001=P) و ﺗﻤﺮﯾﻦ (0/001=P)، اﻧﺴﻮﻟﯿﻦ ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ (0/004=P) و ﺗﻤﺮﯾﻦ (0/005=P)، ﮔﻠﻮﮐﺰ ﻧﺎﺷﺘﺎي ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ (0/001=P) و ﺗﻤﺮﯾﻦ (0/002=BMI ،(P ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ (0/008=P) و ﺗﻤﺮﯾﻦ (0/001=P) و اﻓﺰاﯾﺶ ﻣﻌﻨﯽداري در ﻣﯿﺰان Vo2max ﮔﺮوهﻫﺎي ﺗﻤﺮﯾﻦ-ﻣﮑﻤﻞ (0/001=P) و ﺗﻤﺮﯾﻦ (0/001=P) ﻧﺴﺒﺖ ﺑﻪ ﮔﺮوهﻫﺎي ﻣﮑﻤﻞ و ﮐﻨﺘﺮل ﻣﺸﺎﻫﺪه ﺷﺪ. ﻧﺘﯿﺠﻪﮔﯿﺮي: اﺳﺘﻔﺎده از HIIT در ﺟﻬﺖ ﮐﺎﻫﺶ DPP4، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ، اﻧﺴﻮﻟﯿﻦ، ﮔﻠﻮﮐﺰ ﺧﻮن و ﻧﯿﺰ ﺑﻬﺒﻮد ﺗﺮﮐﯿﺐ ﺑﺪﻧﯽ و ﻋﻤﻠﮑﺮد ﻫﻮازي ﭘﺴﺮان داراي اﺿﺎﻓﻪوزن ﭘﯿﺸﻨﻬﺎد ﻣﯽﺷﻮد.

Background&Purpose: Dipeptidyl peptidase‐4 (DPP4) is known to be an adipocin which associated with insulin resistance. Inhibition of DPP4 leading to increase the body's ability to control the blood glucose and increase fat oxidation. On the other hand, cinnamon stimulates the glucose uptake by activating the insulin receptor. Therefore, the purpose of this study was to investigate the effect of High intensity interval training (HIIT) with supplementation of cinnamon on DPP4 concentration, insulin resistance, insulin, blood glucose, body fat percentage, BMI and Vo2max in overweight boys. Methodology: The subjects subjects (age range: 18-16 years, height: 162-172 cm, weight: 51-61 kg and BMI: 29-25 kg/m2) were purposefully selected and randomly divided into four groups: Training, training-supplementation, supplementation and control. Training and training-supplementation groups completed HIIT for 6 weeks and 3 day/week. Each training session included 3 HIIT (4 minutes at 90% reserve heart rate) with 2 minutes of rest. Subjects in training-supplementation and supplementation groups consumed 3 capsules daily containing 380 mg of cinnamon. The values of DPP4, insulin resistance, insulin, blood glucose, body fat percentage, BMI and Vo2max were evaluated 48 hours ago and after the training program. Tow-way ANOVA were used for statistical analyzes. Results: Significant decrease in the levels of DPP4 in training-supplementation (P = 0.001) and training (P = 0.004) groups, insulin resistance in training-supplementation (P = 0.001) and training (P = 0.001) groups, insulin in training-supplementation (P = 0.005) and training (P = 0.004) groups, glucose in training-supplementation (P = 0.001) and training (P = 0.002) groups and BMI values of training-supplementation (P = 0.008) and training (P = 0.001) groups was observed compared to supplementation and control groups. Also significant increase in the amounts of Vo2max was observed in training-supplementation (P = 0.001) and training (P = 0.001) groups compared to supplementation and control groups. Conclusion: It is recommended that HIIT to be used for decreasing in DPP4, insulin resistance, insulin, blood glucose, and improving the body composition and aerobic performance of overweight boys.