تاﺛﯿﺮ ﻫﺸﺖ ﻫﻔﺘﻪ ﺗﻤﺮﯾﻦ ﺗﺮﮐﯿﺒﯽ ﺑﺮ ﺳﻄﻮح آدروﭘﯿﻦ و اﮐﺴﯿﺪ ﻧﯿﺘﺮﯾﮏ ﺳﺮﻣﯽ زﻧﺎن ﯾﺎﺋﺴﮥ ﻣﺒﺘﻼ ﺑﻪ ﭘﺮﻓﺸﺎرﺧﻮﻧﯽ

The Effect of 8 Weeks of Combined Training on Serum Adropin and Nitric Oxide in Hypertensive Postmenopausal Women

ﭼﮑﯿﺪه اﮔﺮﭼﻪ اﺧﺘﻼل ﻋﻤﻠﮑﺮد اﻧﺪوﺗﻠﯿﺎل و ﮐﺎﻫﺶ اﮐﺴﯿﺪ ﻧﯿﺘﺮﯾﮏ دﻻﯾﻞ ﻓﺸﺎر ﺧﻮن ﯾﺎﺋﺴﮕﯽاﻧﺪ، ﻣﮑﺎﻧﯿﺴﻢﻫﺎي ﭘﺎﯾﻪاي آن ﮐﺎﻣﻼً ﺷﻨﺎﺧﺘﻪﺷﺪه ﻧﯿﺴﺖ. اﺧﯿﺮاً ﺑﻪ ﻧﻘﺶ ﻣﺤﻮري آدروﭘﯿﻦ در اﯾﻦ ﺧﺼﻮص اﺷﺎره ﺷﺪه اﺳﺖ. ﺑﻨﺎﺑﺮاﯾﻦ ﻫﺪف از ﺗﺤﻘﯿﻖ ﺣﺎﺿﺮ ﺑﺮرﺳﯽ اﺛﺮ 8 ﻫﻔﺘﻪ ﺗﻤﺮﯾﻦ ﺗﺮﮐﯿﺒﯽ ﺑﺮ ﺳﻄﻮح آدروﭘﯿﻦ، اﮐﺴﯿﺪ ﻧﯿﺘﺮﯾﮏ ﺳﺮم و ﻓﺸﺎر ﺧﻮن در زﻧﺎن ﯾﺎﺋﺴﮥ ﻣﺒﺘﻼ ﺑﻪ ﭘﺮﻓﺸﺎر ﺧﻮﻧﯽ ﺑﻮد. ﺑﺪﯾﻦﻣﻨﻈﻮر، 20 زن ﯾﺎﺋﺴﮥ ﻣﺒﺘﻼ ﺑﻪ ﭘﺮﻓﺸﺎرﺧﻮﻧﯽ ﻣﺮﺣﻠﮥ 1 ﺑﻪﻃﻮر ﺗﺼﺎدﻓﯽ ﺑﻪ دو ﮔﺮوه ﺗﻤﺮﯾﻦ و ﮐﻨﺘﺮل ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. ﮔﺮوه ﺗﻤﺮﯾﻦ در ﺑﺮﻧﺎﻣﮥ ﺗﻤﺮﯾﻨﺎت ﺗﺮﮐﯿﺒﯽ )ﭘﯿﺎدهروي ﺑﺎ ﺷﺪت ﻣﺘﻮﺳﻂ 60 ﺗﺎ 70 درﺻﺪ ﺣﺪاﮐﺜﺮ ﺿﺮﺑﺎن ﻗﻠﺐ ﺑﯿﺸﯿﻨﻪ( و ﺗﻤﺮﯾﻨﺎت ﻣﻘﺎوﻣﺘﯽ ﺑﺎ ﺷﺪت 10 ﺗﮑﺮار ﺑﯿﺸﯿﻨﻪ )ﻣﻌﺎدل 70 درﺻﺪ 1 ﺗﮑﺮار ﺑﯿﺸﯿﻨﻪ(، 3 روز در ﻫﻔﺘﻪ ﺑﻪ ﻣﺪت 8 ﻫﻔﺘﻪ ﺷﺮﮐﺖ ﮐﺮدﻧﺪ. ﻧﻤﻮﻧﻪﻫﺎي ﺧﻮﻧﯽ ﻗﺒﻞ و ﺑﻌﺪ از اﺟﺮاي ﺑﺮﻧﺎﻣﮥ ﺗﻤﺮﯾﻨﯽ ﺟﻤﻊآوري و ﻏﻠﻈﺖ آدروﭘﯿﻦ ﺑﻪ روش اﻻﯾﺰاي ﺳﺎﻧﺪوﯾﭽﯽ و اﮐﺴﯿﺪ ﻧﯿﺘﺮﯾﮏ ﺳﺮم ﺑﻪ روش ﮐﺎﻟﺮي ﻣﺘﺮي اﻧﺪازهﮔﯿﺮي ﺷﺪﻧﺪ. ﺑﺮاي ﺗﺠﺰﯾﻪوﺗﺤﻠﯿﻞ آﻣﺎري دادهﻫﺎ در ﻫﺮ ﮔﺮوه از آزﻣﻮن ﺗﯽ ﻫﻤﺒﺴﺘﻪ و ﺑﺮاي ﺑﺮرﺳﯽ ﺗﻔﺎوت ﺑﯿﻦ ﮔﺮوهﻫﺎ از آزﻣﻮن ﺗﯽ ﻣﺴﺘﻘﻞ اﺳﺘﻔﺎده ﺷﺪ. ﺳﻄﺢ ﻣﻌﻨﺎداري در ﺗﻤﺎم آزﻣﻮنﻫﺎ 0/05< α در ﻧﻈﺮ ﮔﺮﻓﺘﻪ ﺷﺪ. ﻧﺘﺎﯾﺞ ﻧﺸﺎن داد ﮐﻪ ﺳﻄﻮح آدروﭘﯿﻦ و ﺳﻄﻮح اﮐﺴﯿﺪ ﻧﯿﺘﺮﯾﮏ ﺳﺮم در ﮔﺮوه ﺗﻤﺮﯾﻦ در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﮐﻨﺘﺮل ﺑﻪﻃﻮر ﻣﻌﻨﺎداري اﻓﺰاﯾﺶ ﯾﺎﻓﺖ )0/000 =P(. ﺑﻪﻋﻼوه، ﻓﺸﺎر ﺧﻮن ﺳﯿﺴﺘﻮﻟﯽ و دﯾﺎﺳﺘﻮﻟﯽ ﺑﻪﻃﻮر ﻣﻌﻨﺎداري در ﮔﺮوه ﺗﻤﺮﯾﻦ ﻧﺴﺒﺖ ﺑﻪ ﮐﻨﺘﺮل ﮐﺎﻫﺶ ﯾﺎﻓﺖ )0/000= P(. در ﻣﺠﻤﻮع، ﺑﻪﻧﻈﺮ ﻣﯽرﺳﺪ ﺗﻤﺮﯾﻦ ﺗﺮﮐﯿﺒﯽ از ﻃﺮﯾﻖ اﻓﺰاﯾﺶ آدروﭘﯿﻦ ﺳﺮم و اﮐﺴﯿﺪ ﻧﯿﺘﺮﯾﮏ در ﮐﺎﻫﺶ ﻓﺸﺎر ﺧﻮن زﻧﺎن ﯾﺎﺋﺴﻪ ﻧﻘﺶ دارد.

Even though endothelial dysfunction and reduction of nitric oxide are considered to be responsible for postmenopausal hypertension, the underlying mechanisms are not yet to be fully recognized. Adropin has been shown to play a key role in this regard. Therefore, the aim of this study was to investigate the effect of 8 weeks of combined training on adropin, serum nitric oxide as well as blood pressure in hypertensive postmenopausal women. For this purpose, 20 postmenopausal women with satge-1 hypertension were randomly divided into two groups: training and control. The training group participated in combined exercise (walking with a moderate intensity of 60-70% of maximum heart rate (HRmax)) and resistance training with an intensity of 10 repetitions maximum (equivalent to 70% of 1RM) 3 sessions per week for 8 weeks. Blood samples were collected before and after training intervention. Adropin concentration was measured by sandwich ELISA method and serum nitric oxide was measured by calorimetric method. Dependent and independent t tests were used to analyze and compare the differences within groups and between groups respectively.The significance level was set as α<0.05. The results indicated thatadropin and serum NO levels significantly increased in the training group compared with the control group (P=0.000). Furthermore, systolic and diastolic blood pressures were significantly lower in the training group compared with the control group (P=0.000).In conclusion,it seems that combined training contributes to the reduction of blood pressure in postmenopausal women through an increase in serum adropin and nitric oxide.