تاثير 6 هفته تمرين هوازي در شرايط هايپوكسي بر سطوح استراحتي نسفاتين-1 و مقاومت به انسولين زنان داراي اضافه وزن

The Effect of 6 Weeks of Aerobic Training in Hypoxic Condition on Resting Levels of Nesfatin-1 and Insulin Resistance in Overweight Women

با ﺗﻮﺟﻪ ﺑﻪ ﻧﻘﺶ ﻧﺴﻔﺎﺗﯿﻦ-1 ﺑﻪﻋﻨﻮان ﭘﭙﺘﯿﺪ ﮐﺎﻫﻨﺪة اﺷﺘﻬﺎ و ﻫﻤﭽﻨﯿﻦ ﮐﺎﻫﺶ اﻧﺮژي درﯾﺎﻓﺘﯽ ﻫﻨﮕﺎم ﻗﺮار ﮔﺮﻓﺘﻦ در ﻣﻌﺮض ارﺗﻔﺎع ﺑﺎﻻ ﺗﺤﻘﯿﻖ ﺣﺎﺿﺮ ﺑﺎ ﻫﺪف ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ 6 ﻫﻔﺘﻪ ﺗﻤﺮﯾﻦ ﻫﻮازي در ﺷﺮاﯾﻂ ﻫﺎﯾﭙﻮﮐﺴﯽ ﺑﺮ ﺳﻄﻮح اﺳﺘﺮاﺣﺘﯽ ﻧﺴﻔﺎﺗﯿﻦ-1 و ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ زﻧﺎن داراي اﺿﺎﻓﻪوزن ﻃﺮاﺣﯽ ﺷﺪ. ﺗﻌﺪاد 24 زن ﺟﻮان داراي اﺿﺎﻓﻪوزن )ﺳﻦ 28/25±3/7 ﺳﺎل، ﻗﺪ 161/8±3/01 ﺳﺎﻧﺘﯽﻣﺘﺮ، وزن 78/64±7/18 ﮐﯿﻠﻮﮔﺮم( اﻧﺘﺨﺎب و ﺑﻪ دو ﮔﺮوه )ﺗﻌﺪاد 12 ﻧﻔﺮ، ﻓﻌﺎﻟﯿﺖ 60 درﺻﺪ ﺿﺮﺑﺎن ﻗﻠﺐ ﺑﯿﺸﯿﻨﻪ در ﺷﺮاﯾﻂ ﻫﺎﯾﭙﻮﮐﺴﯽ 3000 ﻣﺘﺮ( و ﻧﻮرﻣﻮﮐﺴﯽ )ﺗﻌﺪاد 12 ﻧﻔﺮ، ﻓﻌﺎﻟﯿﺖ 60 درﺻﺪ ﺿﺮﺑﺎن ﻗﻠﺐ ﺑﯿﺸﯿﻨﻪ در ﺷﺮاﯾﻂ ﻧﻮرﻣﻮﮐﺴﯽ( ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. دورة ﺗﻤﺮﯾﻦ 6 ﻫﻔﺘﻪ و ﺑﻪﺻﻮرت 3 ﺟﻠﺴﻪ در ﻫﻔﺘﻪ ﺑﻮد. وﯾﮋﮔﯽﻫﺎي آﻧﺘﺮوﭘﻮﻣﺘﺮﯾﮏ، ﮔﻠﻮﮐﺰ، اﻧﺴﻮﻟﯿﻦ، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ و ﻧﺴﻔﺎﺗﯿﻦ-ا آزﻣﻮدﻧﯽﻫﺎي ﻗﺒﻞ و ﺑﻌﺪ از دورة ﺗﻤﺮﯾﻨﯽ اﻧﺪازهﮔﯿﺮي ﺷﺪ. از ﺗﯽ-ﻣﺴﺘﻘﻞ و واﺑﺴﺘﻪ ﺑﺮاي ﺗﺤﻠﯿﻞ آﻣﺎري اﺳﺘﻔﺎده ﺷﺪ. ﺑﺮاﺳﺎس ﻧﺘﺎﯾﺞ ﺗﺤﻠﯿﻞ آﻣﺎري ﺗﻔﺎوتﻫﺎي ﺑﯿﻦﮔﺮوﻫﯽ وزن )0/16=P(، ﺷﺎﺧﺺ ﺗﻮدة ﺑﺪن )0/19=P( و ﮔﻠﻮﮐﺰ )0/23=P( ﻣﻌﻨﺎدار ﻧﺒﻮد، اﻣﺎ ﺗﻐﯿﯿﺮات درﺻﺪ ﭼﺮﺑﯽ )0/02=P(، دور ﮐﻤﺮ )0/03=P(، اﻧﺴﻮﻟﯿﻦ )0/001=P(، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ )0/001=P( و ﻧﺴﻔﺎﺗﯿﻦ-1 )0/002=P( ﻣﻌﻨﺎدار ﺑﻮد. ﻧﺘﺎﯾﺞ ﺗﺤﻘﯿﻖ ﻧﺸﺎن داد ﮐﻪ ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﺎ ﺷﺪت ﻣﺘﻮﺳﻂ در ﺷﺮاﯾﻂ ﻫﺎﯾﭙﻮﮐﺴﯽ ﺑﻪ ﺗﻐﯿﯿﺮات ﺑﯿﺸﺘﺮي در ﻧﺴﻔﺎﺗﯿﻦ-1 ﻧﺴﺒﺖ ﺑﻪ ﻓﻌﺎﻟﯿﺖ در ﺷﺮاﯾﻂ ﻧﻮرﻣﻮﮐﺴﯽ ﻣﻨﺠﺮ ﻣﯽﺷﻮد. اﺣﺘﻤﺎل ﻣﯽرود ﺑﻬﺒﻮد ﺗﺮﮐﯿﺐ ﺑﺪن و ﺷﺎﺧﺺ ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ ﺑﺎ ﺗﻐﯿﯿﺮات ﻧﺴﻔﺎﺗﯿﻦ-1 و ﮐﺎﻫﺶ اﺷﺘﻬﺎ و ﻏﺬاي درﯾﺎﻓﺘﯽ ﻧﺎﺷﯽ از آن ﻣﺮﺗﺒﻂ ﺑﺎﺷﺪ.

Nesfatin-1 is an appetite reducing peptide which decreases energy demand in high altitudes. This study aimed at investigating the effect of 6 weeks of aerobic training in hypoxic condition on resting levels of Nesfatin-1 and insulin resistance in overweight women. 24 overweight young women (age: 28.25±3.7 yrs, height: 161.8±3.01 cm, weight: 78.64±7.18 kg) were selected and divided into two experimental groups: hypoxia group (n=12, 60% of HRmax, in hypoxic condition resembling 3000m altitude) and normoxic group (n=12, 60% of HRmax, in normoxic condition). Training program consisted of 6 weeks and 3 sessions per week. Anthropometric characteristics, glucose, insulin, insulin resistance and Nesfatin-1 were measured before and after the training period. Dependent and independent t tests were used for data analysis. Results showed that intergroup differences in weight (P=0.16), BMI (P=0.19) and glucose (P=0.23) were not significant, but changes in fat percent (P=0.02), waist circumference (P=0.03), insulin (P=0.001), HOMA-IR (P=0.001) and Nesfatin-1 (P=0.002) were significant. The results showed that aerobic training with moderate intensity in hypoxic condition leads to more changes in Nesfatin-1 than normoxic condition. It is likely that improvement in body composition and insulin resistance index are associated with Nesfatin-1 changes and appetite reduction and appetite-related nutrition demand