مقايسه تاثير كرم مهبلي روغن نارگيل با كلوتريمازول بر عفونت كانديديايي

Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina

ﺳﺎﺑﻘﻪ و ﻫﺪف: ﻋﻔﻮﻧﺖ ﮐﺎﻧﺪﯾﺪﯾﺎﯾﯽ دوﻣﯿﻦ ﻋﻔﻮﻧﺖ ﺷﺎﯾﻊ ﻣﻬﺒﻞ ﺑﻮده و داروﻫﺎي راﯾﺞ ﻣﻮرد اﺳﺘﻔﺎده در درﻣﺎن آن، آزولﻫﺎ ﻫﺴﺘﻨﺪ. ﻣﺼﺮف ﺑﯿﺶ از ﺣﺪ آزولﻫﺎ، ﺑﺎ اﯾﺠﺎد ﻣﻘﺎوﻣﺖ ﻧﺴﺒﺖ ﺑﻪ دارو و ﺷﮑﺴﺖ درﻣﺎن ﻫﻤﺮاه اﺳﺖ. از آﻧﺠﺎﺋﯿﮑﻪ ﻣﻄﺎﻟﻌﺎت اﻧﺠﺎم ﺷﺪه در ﺷﺮاﯾﻂ آزﻣﺎﯾﺸﮕﺎﻫﯽ ﻣﻮﯾﺪ اﺛﺮات ﺿﺪ ﻗﺎرﭼﯽ روﻏﻦ ﻧﺎرﮔﯿﻞ ﻣﯽﺑﺎﺷﺪ. اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺎ ﻫﺪف ﻣﻘﺎﯾﺴﻪ اﺛﺮ ﮐﺮم ﻣﻬﺒﻠﯽ روﻏﻦ ﻧﺎرﮔﯿﻞ و ﮐﻠﻮﺗﺮﯾﻤﺎزول ﺑﺮ ﻋﻔﻮﻧﺖ ﮐﺎﻧﺪﯾﺪﯾﺎﯾﯽ ﻣﻬﺒﻞ اﻧﺠﺎم ﮔﺮدﯾﺪ. ﻣﻮاد و روشﻫﺎ: اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﮐﺎرآزﻣﺎﯾﯽ ﺑﺎﻟﯿﻨﯽ ﺑﺮ روي 71 زن ﻣﺒﺘﻼ ﺑﻪ ﻋﻔﻮﻧﺖ ﮐﺎﻧﺪﯾﺪﯾﺎﯾﯽ در دو ﮔﺮوه درﯾﺎﻓﺖ ﮐﻨﻨﺪه ﮐﺮم ﻣﻬﺒﻠﯽ روﻏﻦ ﻧﺎرﮔﯿﻞ 35 ﻧﻔﺮ) 78 %( و ﮐﻠﻮﺗﺮﯾﻤﺎزول 36 ﻧﻔﺮ )1%( ﮐﻪ ﺑﻪ ﻣﺪت ﻫﻔﺖ ﺷﺐ )ﺷﺒﯽ ﯾﮏ اﭘﻠﯿﮑﺎﺗﻮر( ﺗﺤﺖ درﻣﺎن ﻗﺮار ﮔﺮﻓﺘﻨﺪ، اﻧﺠﺎم ﺷﺪ. ﯾﮏ ﻫﻔﺘﻪ ﭘﺲ از اﺗﻤﺎم درﻣﺎن، ﺑﯿﻤﺎران ﻣﺠﺪدا ﻣﻌﺎﯾﻨﻪ و ﺑﺮرﺳﯽ آزﻣﺎﯾﺸﮕﺎﻫﯽ اﻧﺠﺎم ﺷﺪ. ﺧﺎرش، ﺳﻮزش، درد و ﺗﺮﺷﺢ در دو ﮔﺮوه ﻣﻘﺎﯾﺴﻪ ﺷﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﭘﺲ از ﻣﺪاﺧﻠﻪ ﻣﯿﺎﻧﮕﯿﻦ )ﺧﺎرش در ﮔﺮوه ﻧﺎرﮔﯿﻞ 0±0 و در ﮔﺮوه ﮐﻠﻮﺗﺮﯾﻤﺎزول p=0/017 - 0/19±0/46ﺳﻮزش در ﮔﺮوه ﻧﺎرﮔﯿﻞ 0/08±0/24 و در ﮔﺮوه ﮐﻠﻮﺗﺮﯾﻤﺎزول p=0/046 - 0/30±0/57ﺗﺮﺷﺢ در ﮔﺮوه ﻧﺎرﮔﯿﻞ 0/05±0/23و در ﮔﺮوه ﮐﻠﻮﺗﺮﯾﻤﺎزول p=0/001 - 0/66±0/98درد ﺣﯿﻦ ﻧﺰدﯾﮑﯽ در ﮔﺮوه ﻧﺎرﮔﯿﻞ 0/05±0/23و در ﮔﺮوه ﮐﻠﻮﺗﺮﯾﻤﺎزول p=0/031 - 0/30±0/62 ﺑﻮد. ﺑﺎ اﯾﻨﺤﺎل ﻣﻮﻓﻘﯿﺖ درﻣﺎﻧﯽ )ﮐﺸﺖ ﻣﻨﻔﯽ( ﺑﯿﻦ دو ﮔﺮوه ﺗﻔﺎوت آﻣﺎري ﻣﻌﻨﯽدار ﻧﺪاﺷﺖ. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﻧﺸﺎن داد ﮐﺮم ﻣﻬﺒﻠﯽ روﻏﻦ ﻧﺎرﮔﯿﻞ و ﮐﻠﻮﺗﺮﯾﻤﺎزول ﻫﺮ دو ﺳﺒﺐ ﺑﻬﺒﻮد ﻋﻔﻮﻧﺖ ﮐﺎﻧﺪﯾﺪﯾﺎﯾﯽ ﻣﻬﺒﻞ ﻣﯽﺷﻮﻧﺪ. ﺑﻨﺎﺑﺮاﯾﻦ ﻣﯽﺗﻮان از ﮐﺮم ﻣﻬﺒﻠﯽ روﻏﻦ ﻧﺎرﮔﯿﻞ ﺑﻌﻨﻮان درﻣﺎن ﺟﺎﯾﮕﺰﯾﻦ در ﻋﻔﻮﻧﺖ ﮐﺎﻧﺪﯾﺪﯾﺎﯾﯽ ﻣﻬﺒﻞ ﻧﯿﺰ اﺳﺘﻔﺎده ﻧﻤﻮد.

Candidiasis is the second common vaginal infection, and commonly used drugs are azoles. Over-consumption of Azol is associated with resistance to drug and treatment failure. Studies conducted in vitro confirm the antifungal effects of coconut oil. The aim of this study was to compare the effect of vaginal cream of coconut oil and clotrimazole on vaginal candidiasis infection. METHODS This clinical trial study was performed on 71 women with Candida infection in two groups receiving vaginal cream of coconut oil: 35(78%) and clotrimazole (36%) (1%) who were treated for 7 nights (one applicator per night). One week after the completion of the treatment, patients were re-examined. Itching, burning, pain and secretion were compared in two groups. FINDINGS After the mean intervention (itching in the coconut group was 0±0 and in the clotrimazole group was 19±0.46 (p=0.017), (burning in the coconut group was 0.08±0.20 and in the clotrimazole group was 57% (p=0.046), (secretion in the coconut group was 0.05±0.23 and in the clotrimazole group was 66.6 ± 0.98 (p=0.001) (pain during sex in the coconut group 23 0.05 and 0.30±0.62 in the clotrimazole group (p=0.031). However, the success of the treatment (negative culture) was not significant between the two groups (p<0.05). CONCLUSION The present study showed that vaginal cream of coconut oil and clotriamzole both improve vaginal candidiasis infection. Therefore, vaginal cream of coconut oil can be used as an alternative treatment for vaginal candidiasis