نكروز جلدي پس از تزريق سديم استيبوگلوكونات جهت درمان ليشمانيوز جلدي: گزارش يك مورد نادر

Cutaneous Necrosis after the Injection of Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasis: A Rare Case Report

بيمار آقاي 23 ساله اهل و ساكن يكي از مناطق شرقي استان اصفهان از دو ماه قبل دچار ضايعه ي پاپول شكل در ناحيه ي روي پاي چپ (ليسفرانك) شدند. اين ضايعه در طي چندين هفته پيشرفت نمود و نماي ندولو اولسراتيو مشهود گرديد. بيمار توسط مركز پزشكي محلي ويزيت و معاينه شد كه با احتمال عفونت بافت نرم، تحت درمان با داروي سفالكسين خوراكي با دز 550 ميلي گرم هر شش ساعت قرار گرفت، اما بهبود باليني حاصل نشد.

A 32-year-old man was diagnosed with cutaneous leishmaniasis, and intradermal Sodium Stibogluconate was injected for him. After two days, the injection site became erythematous, and a progressive necrotizing lesion appeared; hence, the patient diagnosed with soft tissue infection. Antibiotic therapy and debridement initiated for him. Cutaneous adverse effect of Sodium Stibogluconate is not common, and among them, coetaneous necrosis is rare. Sodium Stibogluconate is a mixture of complex compound, and it is not a simple medicine. A probable mechanism of necrosis formation in this case is hypersensitivity reactions. Hence, it is suggested to avoid intradermal injection of this medicine, especially those brands which do not claim intradermal injection allowance