تاثير 12 هفته تمرين تركيبي همراه با مصرف خرفه بر پروفايل ليپيدي و پارانشيم كبدي زنان چاق مبتلا به كبد چرب غيرالكلي: يك كارآزمايي باليني تصادفي شده

The Effects of Twelve Combined Training and Portulaca Oleracea Supplementation on Lipid Profile and Liver Parenchyma in Obese Females with non - Alcoholic Fatty Liver Disease: A Clinical Trial

مقدمه: بيماري كبد چرب غيرالكلي، نوعي تجمع چربي در سلول هاي كبدي است. گياه خرفه داراي ويژگي هيپوليپدميك مي باشد، بنابراين هدف از پژوهش اثر تمرين تركيبي و مكمل خرفه بر پروفايل ليپيدي و پارانشيم كبدي زنان چاق مبتلا به كبد چرب غيرالكلي است. مواد و روش ها: جامعه آماري پژوهش حاضر را زنان چاق 60-40 سال مبتلا به كبد چرب غيرالكلي تشكيل دادند. 40 زن چاق مبتلا به كبد چرب غيرالكلي به صورت تصادفي به 4 گروه تمرين تركيبي با مكمل خرفه (10 نفر)، دارونما (10 نفر)، تمرين تركيبي (10 نفر) و مكمل خرفه (10 نفر) تقسيم شدند. پيش و پس از مداخله سونوگرافي از كبد و آزمايش خون انجام شد. از آزمون تي همبسته، آزمون تحليل واريانس يك طرفه و آزمون ويلكاكسون استفاده گرديد. سطح معني داري نيز 0/05

Introduction Non-alcoholic fatty liver disease is a type of accumulation of fat in the liver cells. Portulaca oleracea has hypolipidemic properties, therefore the aim of this study was to investigate the effect of twelve combined training and portulaca oleracea supplementation on lipid profile and liver parenchyma in obese females with non - alcoholic fatty liver disease. Methods The study population consisted of obese women (40-60 years) with non-alcoholic liver fatty. 40 obese females with non -alcoholic fatty liver disease were randomly divided into four groups of combined training with portulaca oleracea (n=10), placebo (n=10), portulaca oleracea (n=10) and combined training (n=10). Before and after the intervention sonography of parenchyma of the liver and blood tests were performed .the paired samples t-test, one-way anova and wilcoxon test was used. The significant level was determine at P<0.05. Results 12 weeks of portulaca oleracea supplementation and combined training caused significant decrease in profile lipid and significant increase HDL serum level in combined training with supplement group, supplement and combined training groups (P<0.05). liver parenchyma also improved in training with supplement group and training group. Conclusion Portulaca oleracea supplementation with combination training can be effective in decrease profile lipid and improving liver parenchyma in obese females with nonalcoholic fatty liver.