بدنبال واكسيناسيون بعد از يك دوره 6-5 ساله در كودكان تازه وارد به دبستان در شهرستان شهركرد B سطح آنتي بادي بر عليه آنتي ژن سطحي ويروس هپاتيت

Antibody Titer Against HBsAg in Children Entering Elementary School Who Were Vaccinated Against Hepatitis B at Birth: Shahr-e-Kord City

Introduction. Regarding the fact that hepatitis B and its complications is a serious problem routine vaccination against it is recommended at birth. Fortunately, since 1991 all infants in our country are vaccinated against the disease. This study was designed to evaluate hepatitis B vaccine induced immunity 5-6 years after vaccination. If antibody titer is below the protective level booster dose should be considered. Methods. This study is a cross-sectional one which 394 cases selected randomly. After filling up questionnaires sampling was performed and sample sera were checked out for anti HBsAg antibody by EL/SA method. Results were announced as positive and negative. Some variables Such as age, gender, growth and development and time of vaccination also were evaluated. Results. From the total number of 394 cases, 142 (36 percent) had antibody titer less than (10 MIU) which is not protective. Rate of negative response was 32.2 percent for girls and 39 percent for boys. The same rate for children of 2-2.5, 2.5-3.5 and over 3 kg weight at birth was 44 percent, 36 percent and 34.8 percent respectively. Regarding the time, 16 cases had delayed vaccination with 44 percent negative response. Rate of negative response in children who received regular vaccination was 35.7 percent. Negative response rate for 25 cases above the acceptable level of growth was 8 percent and for 6 cases below the level was 17 percent. In rural and urban population negative response rate was 35.4 percent and 36.7 percent respectively. Discussion. Cases with negative response are susceptible to infection so it is recommended to 1: Carryout investigations to determine causes of decline in antibody titer. 2: Carryout investigations in other parts of country to recheck the results of this study. 3: administer booster dose to high-risk cases with negative response.