اثر هشت هفته تمرينات ايروبيك و مكمل ياري نانو كوركومين بر سطوح سرمي پروتئين آميلوئيد A و شاخصهاي تركيب بدني زنان داراي اضافه وزن و چاق

Effectiveness of Eight Weeks Aerobic Training and Nano Curcumin Supplementation on Serum Amyloid A Protein Content and Body Composition in Overweight and Obese Women

ﻣﻘﺪﻣﻪ: آﻣﯿﻠﻮﺋﯿﺪ )A (SAA ﯾﮏ ﻣﺎرﮐﺮ ﺣﺴﺎس ﺣﺎﻟﺖ اﻟﺘﻬﺎﺑﯽ ﺣﺎد اﺳﺖ و در ﮐﺒﺪ ﺳﺎﺧﺘﻪ ﻣﯽﺷﻮد و ﻧﻘﺶ دﻓﺎﻋﯽ و ﺗﺮﻣﯿﻢ در ﻓﺮاﯾﻨﺪ اﻟﺘﻬﺎب دارد. ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ )رﻧﮕﺪاﻧﻪ زردﭼﻮﺑﻪ( ﯾﮏ ﻣﺎده ﺿﺪاﻟﺘﻬﺎﺑﯽ و آﻧﺘﯽ اﮐﺴﯿﺪاﻧﯽ اﺳﺖ. ﻫﺪف از اﯾﻦ ﻣﻄﺎﻟﻌﻪ، ﺑﺮرﺳﯽ ﯾﮏ دوره ﺗﻤﺮﯾﻦ اﯾﺮوﺑﯿﮏ و ﻣﮑﻤﻞ ﯾﺎري ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ ﺑﺮ ﺷﺎﺧﺺﻫﺎي ﺗﺮﮐﯿﺒﺒﺪﻧﯽ و آﻣﯿﻠﻮﺋﯿﺪ ﺳﺮم A زﻧﺎن داراي اﺿﺎﻓﻪ وزن و ﭼﺎق اﺳﺖ. روش ﮐﺎر: در ﻣﻄﺎﻟﻌﻪ ﻧﯿﻤﻪ ﺗﺠﺮﺑﯽ ﺣﺎﺿﺮ، 44 زن )ﻣﯿﺎﻧﮕﯿﻦ ﺳﻦ 3/33 ± 28/7 ﺳﺎل، ﺷﺎﺧﺺ ﺗﻮده ﺑﺪﻧﯽ 4/86 ± 31/53 ﮐﯿﻠﻮﮔﺮم ﺑﺮ ﻣﺘﺮ ﻣﺮﺑﻊ و ﻧﺴﺒﺖ دور ﮐﻤﺮ ﺑﻪ ﻟﮕﻦ 0/07 ± 0/82 ﺳﺎﻧﺘﯽ ﻣﺘﺮ( ﺑﺼﻮرت ﻫﺪﻓﻤﻨﺪ اﻧﺘﺨﺎب و ﺑﻪ ﻃﻮر ﺗﺼﺎدﻓﯽ در ﭼﻬﺎر ﮔﺮوه ﺗﻤﺮﯾﻦ )12 ﻧﻔﺮ(، ﺗﻤﺮﯾﻦ+ ﻧﺎﻧﻮﮐﻮرﮐﻮﻣﯿﻦ )12 ﻧﻔﺮ(، ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ )10 ﻧﻔﺮ( و ﮐﻨﺘﺮل )10 ﻧﻔﺮ( ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ و ﺑﻪ ﻣﺪت 8 ﻫﻔﺘﻪ ﺑﻪ اﻧﺠﺎم ﺗﻤﺮﯾﻦ اﯾﺮوﺑﯿﮏ و ﻣﺼﺮف روزاﻧﻪ ﯾﮏ ﮐﭙﺴﻮل 80 ﻣﯿﻠﯽ ﮔﺮم ﻧﺎﻧﻮﻣﯿﺴﯿﻞ ﭘﺮداﺧﺘﻨﺪ. داده ﺑﺎ اﺳﺘﻔﺎده از آزﻣﻮن ﺗﯽ ﻣﺴﺘﻘﻞ و زوﺟﯽ و ﮐﻮوارﯾﺎﻧﺲ و آزﻣﻮن ﺗﻌﻘﯿﺒﯽ ﺑﻮﻧﻔﺮوﻧﯽ ﺗﺠﺰﯾﻪ و ﺗﺤﻠﯿﻞ ﺷﺪ و )0/05 < P( ﻣﻌﻨﯽ دار ﺗﻠﻘﯽ ﮔﺮدﯾﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﻫﺸﺖ ﻫﻔﺘﻪ ﺗﻤﺮﯾﻦ اﯾﺮوﺑﯿﮏ، ﻣﺼﺮف ﻣﮑﻤﻞ ﯾﺎري ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ و ﻫﻤﭽﻨﯿﻦ اﺛﺮ ﺗﻮاﻣﺎن ﺗﻤﺮﯾﻦ و ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ ﺳﺒﺐ ﮐﺎﻫﺶ ﻣﻌﻨﯽ داري در ﺳﻄﻮح ﺳﺮﻣﯽ آﻣﯿﻠﻮﺋﯿﺪ A و ﻣﻘﺎدﯾﺮ وزن ﺑﺪن و ﺷﺎﺧﺺ ﺗﻮده ﺑﺪﻧﯽ ﻣﯽﺷﻮد )0/05 < P(. ﺑﯿﻦ ﻣﯿﺎﻧﮕﯿﻦ ﺗﻤﺮﯾﻦ اﯾﺮوﺑﯿﮏ و ﮐﻨﺘﺮل و ﻫﻤﭽﻨﯿﻦ ﺗﻤﺮﯾﻦ ﺑﻪ ﻫﻤﺮاه ﻣﮑﻤﻞ ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ ﺑﺎ ﮐﻨﺘﺮل ﺗﻐﯿﯿﺮات ﻣﻌﻨﯽ داري ﻣﺸﺎﻫﺪ ﺷﺪ )0/05 < P(؛ اﻣﺎ ﻧﺴﺒﺖ دور ﮐﻤﺮ ﺑﻪ ﻟﮕﻦ در ﺗﻤﺎﻣﯽ ﮔﺮوه ﭘﮋوﻫﺶ ﮐﺎﻫﺶ ﻣﻌﻨﯽ داري ﻧﺪاﺷﺖ )0/05 > P(. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: ﺑﻪ ﻧﻈﺮ ﻣﯽرﺳﺪ ﺗﻤﺮﯾﻦ اﯾﺮوﺑﯿﮏ و ﻧﺎﻧﻮ ﮐﻮرﮐﻮﻣﯿﻦ ﺑﻪ واﺳﻄﻪ ﮐﺎﻫﺶ ﻋﻮاﻣﻞ اﻟﺘﻬﺎﺑﯽ، ﻣﯽﺗﻮاﻧﺪ در ﮐﺎﻫﺶ وﺿﻌﯿﺖ اﻟﺘﻬﺎﺑﯽ در زﻧﺎن داراي اﺿﺎﻓﻪ وزن و ﭼﺎق و ﻫﻤﭽﻨﯿﻦ ﮐﺎﻫﺶ وزن ﺑﺪن ﻣﺆﺛﺮ ﺑﺎﺷﺪ.

Serum Amyloid A (SAA) is a sensitive marker related to the acute inflammatory phase, produced in the liver, and has got the protection and repair role in the inflammatory process. Nano curcumin (turmeric pigment) is anti-inflammatory and antioxidant. The purpose of this study was to evaluate the impact of advanced aerobic training and Nano curcumin supplementation on body composition and SAA levels in overweight and obese women. Methods In this quasi-experimental study،The Forty-Four women with (age 28.7 ± 3.33 years, BMI 31.53 ± 4.86 kg/m2 and WHR 0.82 ± 0.07 cm) above 25 kg/m2 were selected purposefully and were randomly divided into four groups of advanced aerobic training (n = 12), advanced aerobic training+ Nano curcumin (n = 12), Nano curcumin (n = 10) and control (n = 10) and for 8 weeks, they performed advanced aerobic exercise and daily intake of a Nano curcumin 80 m/g nanomicelle capsule. The Nano curcumin and control groups had no physical activity during the period. Fasting blood samples were taken 24 hours before and 48 hours after the last training session and serum levels were measured by ELISA using human kits. For data normality, K-S test and dependent t-test and analysis of ANOVA were used to test the hypothesis. Results The results showed that eight weeks of training ،supplementation ،and train +supplementation group significantly decreased SAA about pre-exercise values (P =0.001) There was also a significant difference between the four groups (P < 0.05). Conclusions Improved aerobic exercise and Nano curcumin appear to be effectivein reducing the inflammatory status of overweight and obese women as well as inreducing body weight by reducing inflammatory factors.