ﺑﺮرﺳﯽ اﺛﺮﺑﺨﺸﯽ ﻣﮑﻤﻞ ﭼﺎي ﺳﺒﺰ در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﻣﮑﻤﻞﻫﺎي ﻓﯿﺒﺮ، ﮐﺎﻓﺌﯿﻦ و الﮐﺎرﻧﯿﺘﯿﻦ ﺑﺮ ﮐﺎﻫﺶ وزن در اﻓﺮاد ﭼﺎق )ﯾﮏ ﻣﺘﺎآﻧﺎﻟﯿﺰ ﺷﺒﮑﻪاي(

A Survey on Clinical Effectiveness of Green Tea Supplementation Compared to Fiber, Caffeine and L-carnitine Supplements on Weight Loss: a Network Meta-Analysis

زﻣﯿﻨﻪ ﺗﺎﮐﻨﻮن ﻣﻄﺎﻟﻌﻪاي، ﻣﯿﺰان اﺛﺮﺑﺨﺸﯽ ﺟﺎﻣﻊ ﻣﮑﻤﻞ ﭼﺎي ﺳﺒﺰ را ﻧﺴﺒﺖ ﺑﻪ ﻓﯿﺒﺮ، ﮐﺎﻓﺌﯿﻦ و الﮐﺎرﻧﯿﺘﯿﻦ ﺑﺮ ﮐﺎﻫﺶ وزن اﻓﺮاد ﭼﺎق ﺗﻌﯿﯿﻦ ﻧﮑﺮده اﺳﺖ. ﺑﻨﺎﺑﺮاﯾﻦ ﻫﺪف از اﯾﻦ ﻣﻄﺎﻟﻌﻪ، ارزﯾﺎﺑﯽ ﺟﺎﻣﻊ ﻣﮑﻤﻞ ﭼﺎي، ﻓﯿﺒﺮ، ﮐﺎﻓﺌﯿﻦ و الﮐﺎرﻧﯿﺘﯿﻦ ﺑﺮ ﮐﺎﻫﺶ وزن در اﻓﺮاد ﭼﺎق ﻣﯽﺑﺎﺷﺪ. روش ﮐﺎر ﭘﺎﯾﮕﺎهﻫﺎي اﻃﻠﺎﻋﺎﺗﯽ ﭘﺎﺑﻤﺪ، اﺳﮑﻮﭘﻮس و ﮐﺎﮐﺮن ﺗﺎ ﺗﺎرﯾﺦ آﺑﺎنﻣﺎه 1397 ﺟﺴﺘﺠﻮ ﺷﺪ. از روش pairwise ﺑﺮاي ﻣﻘﺎﯾﺴﻪ اﺧﺘﻠﺎف ﻣﯿﺎﻧﮕﯿﻦ ﮐﺎﻫﺶ وزن داروﻫﺎ در دو روش ﻣﺴﺘﻘﯿﻢ )ﻣﻘﺎﯾﺴﻪ داروﻫﺎ ﺑﺎ ﮔﺮوه ﮐﻨﺘﺮل( و ﻏﯿﺮﻣﺴﺘﻘﯿﻢ ﻣﻘﺎﯾﺴﻪ داروﻫﺎ ﺑﺎ ﯾﮑﺪﯾﮕﺮ( اﺳﺘﻔﺎده ﺷﺪ. ﯾﺎﻓﺘﻪﻫﺎ ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﮐﻪ ﺑﺮ روي 73 ﻣﻄﺎﻟﻌﻪ ﺑﺎﻟﯿﻨﯽ ﺑﺎ ﺟﻤﻌﯿﺖ 3921 )2002 ﻧﻔﺮ ﮔﺮوه ﻣﺪاﺧﻠﻪ و 1919 ﮔﺮوه ﮐﻨﺘﺮل( ﻧﺸﺎن داد ﮐﻪ ﻣﮑﻤﻞ ﮐﺎﻓﺌﯿﻦ )0/88- ﮐﯿﻠﻮﮔﺮم، ﻓﺎﺻﻠﻪ اﻃﻤﯿﻨﺎن 2/60- ﺗﺎ 0/84-( و ﺑﻌﺪ از آن ﻣﮑﻤﻞ ﺗﺮﮐﯿﺒﯽ ﮐﺎﻓﺌﯿﻦ ﺑﺎ ﮐﺎﺗﭽﯿﻦ )0/74- ﮐﯿﻠﻮﮔﺮم، ﻓﺎﺻﻠﻪ اﻃﻤﯿﻨﺎن 1/70- ﺗﺎ 0/21-(، ﭼﺎي )0/61- ﮐﯿﻠﻮﮔﺮم، ﻓﺎﺻﻠﻪ اﻃﻤﯿﻨﺎن 1/33- ﺗﺎ 0/11-(، ﻓﯿﺒﺮ)0/31- ﮐﯿﻠﻮﮔﺮم، ﻓﺎﺻﻠﻪ اﻃﻤﯿﻨﺎن 0/79- ﺗﺎ 0/17-(، ﺑﻪ ﺗﺮﺗﯿﺐ ﺑﯿﺸﺘﺮﯾﻦ ﺗﺄﺛﯿﺮ را در ﮐﺎﻫﺶ وزن در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﮔﺮوه داروﻧﻤﺎ دارﻧﺪ، ﺑﻪ ﻫﺮ ﺣﺎل ﻣﮑﻤﻞ ﮐﺎرﻧﯿﺘﯿﻦ، ﺗﺄﺛﯿﺮي ﺑﺮ ﮐﺎﻫﺶ وزن ﻧﺪاﺷﺖ. ﻧﺘﯿﺠﻪﮔﯿﺮي ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﻧﺸﺎن داد ﮐﻪ اﺛﺮﺑﺨﺸﯽ ﻣﮑﻤﻞ ﭼﺎي ﺳﺒﺰ در ﮐﺎﻫﺶ وزن در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﻓﯿﺒﺮ و ﮐﺎرﻧﯿﺘﯿﻦ،ﺑﯿﺸﺘﺮ و در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﮐﺎﻓﺌﯿﻦ و ﺗﺮﮐﯿﺐ ﮐﺎﻓﺌﯿﻦ ﺑﺎ ﮐﺎﺗﭽﯿﻦ، ﮐﻤﺘﺮ ﻣﯽﺑﺎﺷﺪ.

Introduction: No study compared the effectiveness of the green tea, fiber, caffeine and L-carnitine on weight loss in individuals. Therefore, the aim of this study was to evaluate the efficacy of green tea, fiber, caffeine and L-carnitine in clinical aspects of people. Materials and Methods: The databases of Pubmed, Scopus and Cochran were searched up to November 2018. The pairwise method was used to compare the difference between the mean weight loss of drugs in two direct methods (comparison of drugs with the control group) and non-direct (Compare medications together). Results: The present study performed on 73 clinical studies with a cumulative population of 3921, showed that caffeine (-0.88 kg; -2.60 to - 0.84), caffeine + catechine (-0.74 kg; -1.70 to 0.21), green tea (-0.61 kg; -1.33 to -0.11), fiber (-0.31 kg; -0.79 to -0.17), respectively, had the most effect on weight loss compared with the placebo group. In addition, carnitine supplementation did not effect on weight loss. Conclusion: The present study indicated that green tea supplementation had a lower effect on weight loss compared with caffeine and caffeine+catechin, and had a greater effect on weight loss compared with fiber and carnitine.