بررسي اثر شياف ديكلوفناك بر روي سير درماني پانكراتيت حاد صفراوي

Effect of Diclofenac Suppository on Treatment of Acute Biliary Pancreatitis

زمينه و هدف: پانكراتيت حاد يك بيماري التهابي پانكراس است كه ممكن است همراه با فيبروز باشد. درمان غير جراحي استاندارد در تمام بيماران شامل اصلاح اختلالات آب و الكتروليت، ضد درد و اجتناب از تحريك پانكراس است.با توجه به اينكه پانكراتيت يك پروسه­ ي التهابي مي­ باشد و داروهاي NSAID باعث تعديل پروسه ­هاي التهابي مي­ شوند، بر آن شديم كه در اين مطالعه تاثير داروي ديكلوفناك را بر روي سير درماني پانكراتيت­هاي حاد صفراوي را ارزيابي كنيم. مواد و روش­ها: اين مطالعه بر روي 79 نفر مبتلا به پانكراتيت حاد صفراوي انجام شد. گروه مداخله علاوه بر درمان استاندارد شياف ديكلوفناك 100 ميلي ­گرم و گروه كنترل شياف پلاسبو دريافت كردند. اين مطالعه دوسو كور بوده و اثر شياف ديكلوفناك را برروي سير درمان پانكراتيت حاد بررسي شد. يافته­ ها: نتايج نشان داد كه اختلاف معني­داري بين دو گروه از نظر جنس و سن وجود نداشت (0/05

Background and Aim: Acute pancreatitis is an inflammatory pancreatic disease that is associated with low or no fibrosis of the pancreas. Standard non-surgical treatment in all patients involves correcting water and electrolyte disorders, pain relief and avoiding pancreatic secretion. Given that pancreatitis is an inflammatory process, and NSAIDs have been shown to modulate inflammatory processes and even prevent pancreatitis in those who received ERCP, as well as complete studies on this issue, we concluded that In this study, we evaluated the effect of diclofenac on the treatment of acute biliary pancreatitis. Materials and Methods: This study was performed on 79 patients with acute biliary pancreatitis. The two groups received the standard treatment of acute pancreatitis and the intervention group received 100 mg diclofenac suppository and the control group received placebo suppository excessive to the standard treatment. This double-blind study was conducted to investigate the effect of diclofenac suppository on the treatment of acute pancreatitis. Results: The results showed that there was no significant difference between sexes and age (p>0.05). Also, there were no significant differences between the two groups in terms of mortality, cholangitis, organ failure, bactericidal necrotizing pancreatitis, cholangitis, intrathecal or extracellular pancreatic insufficiency, necrotizing surgery, length of stay in the hospital and hospitalization in the care unit there were no special cases (P> 0.05). Conclusion: Diclofenac suppositories have not had a positive effect on the treatment of acute biliary pancreatitis.