در دو بيمارستان امام حسين و خاتم الانبياء طي سالهاي 83-1381 AFP بررسي ارتباط خصوصيات كلينيكوپاتولوژيك آدنوكارسينوهاي معده غير متاستاتيك با آلفافيتوپروتيين سرم

Relationship between the clinicopathologic features of gastric adenocarcinoma and serum cancentration of AFP

Background: Role of serum AFP as a tumor marker and prognostic factors in gastric adenocarcinoma is doubtful. This study was performed to determine the reltaionship between clinicopathological features of patients with non metastatic gastric cancer and serum AFP in Imam hossein hospital and Khatam al anbia hospital during period of 1381-1383. Materials and methods: In this cross-sectional study, all of the patients with non metastatic gastric adenocarcinoma cancer were studied and their clinicopathological feature of disease(liver metastasis, peritoneal seeding pathologic stage, resectability) and serum AFP were determined . Values more than 20IU/ml were considered as high serum AFP (or abnormal) and clinicpathofogic features of disease eveluated statistically. Results: From 96 patients with gastric cancer (non metastatic) only 9 patient had abnormal AFP.There was a significant relationship between resectability and pcritioneal seeding with elevation of AFP(p<0.05), but not between AFP elevation with Conclusion: According to this study, AFP is an important factor to diagnosis the non-metastatic gastric adenocarcinoma,Since this test is feasible and low price ,it is suggested to be done in these patients. Because ,resectability and peritoneal seeding are unresectable in patients with abnormal AFP, we recommend to do laparascopy before surgery to prevent unnecessary surgery and propose connection between AFP value, peritoneal seeding and resectability in analytical research.