PICA مقايسه تاثير درماني و عوارض تجويز كلوپيداگرل پيدين پس از آنژيوپلاستي عروق كرونر با استنت

Comparative clinical efficasy and safety of Ticlopidine and Clopidogrel following coronary stent- angioplasty

Background: Coronary artery disease is the most common cause of death worldwide and angioplasty is one of the most effective modality of treatment. Ticlopidine and clopidogrel , as antiplatelet drugs, have been used to prevent the development of recurrent stenosis in these patients. The aim of this study was comparison of drugs efficasy and side effects in coronary stent patients. Materials and methods: In this sequential randomized double blind clinical trial , the effectiveness and cardiac & non-cardiac side effects of two antiplatelet drugs (clopidogrel & ticlopidine) were compared. All patients regardless age or number of diseased coronary arteries who underwebt sent angioplasty between Feb. 200(1 Feb. 2002 in Shaheed modarres hospital were randomly divided between two groups.Patients in case group received ticlopidine + ASA and controls received clopiogrel + ASA for a month. During the period of 3 months followup, all patients were evaluated for GI, skin, cardiovascular and hematological complications by means of direct examination, periodic CBC(every 2 weeks) and exercise test (after 8 months). Results: Follow up of 196 patients were completed. Regarding cardiac events (ie: Mi, Unstable angina, Abrupt closure and death) no significant difference was noted between two groups. Although leukopenia, thrombocytopenia, bleeding, G1 & skin cruptions were more frequent in ticlopidine group hut these differences were not statistiacally significant. Number of restenosis cases ( following angiography) were equal between two groups which was comparable with other stuies. Conclusion: On the basi study should continue to cover adequate sample size for final analysis.