تاثير مصرف اسيدهاي چرب امگا - 3 بر شاخص هاي اتهابي حساسيت انسوليني و كنترل متابوليك بيماران ديابتي نوع دو

Effect of omega-3 fatty acids on inflammatory mediators, insulin sensivity and metabolic control in patients with type 2 diabetes

Background: Type 2 diabetes mellitus may represent a disease of the innate immune system responsible for an ongoing cytokine-mediated acute phase response and fish oil may suppress inflammatory mediator .The ability of omega-3 fatty acids from fish oil to suppress inflammatory mediators and and its consequent effect on glycemia, serum lipids, blood pressure and insulin sensitivity was studied in a clinical trial on patients with type 2 diabetes mellitus. Materials and methods:A total of 26 (10 male and 16 female) were given 3000 mg omega-3 fatty acids, daily, for 8 weeks.the serum level of inflammatory determinats and biochemical ultrasensors were measured by kits ,and aquestionnair based on body measurment(anthropometric indexes),medical data was completed. Results: All 26 cases (10 male, l6 female) full filled the study.mean age , acquiring DM,body mass index were 52.7 9.2 years (1SD), 9 6.0 years,and 27.32 2.9 years respectively. The results of this study showed there were no significant differences in fasting blood glucose and insulin at baseline, week 4 and week 8 after supplementation despite a significant decrease in serum sialic acid triglycerides, cholesterol and blood pressure were decreased. Conclusion: A moderate dose of omega-3 fatty acids did not lead to deleterious effects on glycemia control in patients with type 2 diabetes mellitus, with preserved beneficial capacities.