بررسي تاثير استروژن كونژوگه خوراكي در عمل جراحي لوزه

Background: Tonsillectomy is a common operation among children, where hemorrhage is its most frequent complication. Some reports have stated the efficacy of conjugated estrogen on coagulation indices. Thus, in order to study the effects of conjugated estrogen in tonsillectomy, the present study was conducted in Taleghani Hospital in 1997. Materials and methods: During this clinical trial, 50 children under 14 years of age were operated. Patients were assigned randomly in either case or control group. Coagulation profile including BT, CT, PT, and PTT was determined before the study. Patients of the case group were given one tablet of conjugated estrogen (0.625 mg). Coagulation profile was determined again. Results: The mean volume of intraoperative bleeding to weight was remarkably lower in case group, but the difference was not statistically significant. Bleeding time was reduced significantly (p<0.002) in the case group. There was no valuable change in other coagulation tests. Meanwhile, no complication has been reported. Conclusion: Conjugated estrogen can improve BT. Further experimental studies are strongly recommended.