عنوان مقاله :
Screening of Apiaceae fruits discovered natural resources with considerable biological potential
پديد آورندگان :
Tofighi ، Zahra Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy, Medicinal Plants Research Center , Pirali Hamedani ، Mostafa Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Tavakoli ، Saeed ACECR - Institute of Medicinal Plants - Medicinal Plants Research Center , Tabatabaei ، Javad Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Rabei ، Marzieh Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Mohtadi ، Shamim Tehran University of Medical Sciences - International Campus, ICTUMS , Mirghaffari ، Farnoosh Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Afshani ، Maryam Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Kahrizi ، Farhad Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Khodabandeloo ، Behruz Tehran University of Medical Sciences - Faculty of Pharmacy - Department of Pharmacognosy , Jafari-Nodooshan ، Saeede Tehran University of Medical Sciences - School of Advanced Technologies in Medicine - Department of Molecular Medicine , Shirzad ، Mahdieh Tehran University of Medical Sciences - School of Advanced Technologies in Medicine - Department of Molecular Medicine , Motevaseli ، Elahe Tehran University of Medical Sciences - School of Advanced Technologies in Medicine - Department of Molecular Medicine , Goodarzi ، Saied Tehran University of Medical Sciences - Faculty of Pharmacy - Medicinal Plants Research Center
كليدواژه :
Umbelliferae , Fruits , Cytotoxic , Reducing power , Phenol content ,
چكيده فارسي :
Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for further investigation including cancer prevention. Methods: Fruits of Apium graveolens L. (celery), Bunium persicum (Boiss.) B.Fedtsch. (black cumin), Petroselinum crispum (Mill.) Fuss (parsley), Pimpinella anisum L. (anise), Trachyspermum ammi (L.) Sprague (ajwain), Coriandrum sativum L. (coriander), Foeniculum vulgare Mill. (fennel), Anethum graveolens L. (dill), Heracleum persicum Desf. ex Fisch., C.A.Mey. Av eacute;Lall. (Persian hogweed), Ferula assafoetida L. (asafoetida), Cuminum cyminum L. (cumin) and Daucus carota L. (carrot) were extracted with 80 % methanol and fractionated by petroleum ether, chloroform, ethyl acetate and methanol, respectively. For different fractions and total extract of all 12 samples, cytotoxicity by brine shrimp test (BST) and MTT assay against cancer and normal cell (foreskin fibroblast cells), antioxidant effects by FRAP, and total phenols by FolinCiocalteu method were measured. Results: The general toxicity of ethyl acetate fractions (mean of data) was higher than others in the brine shrimp test (P 0.05). The most cytotoxic fractions against colon carcinoma (HT29), breast adenocarcinoma (MDAMB231) and alveolar basal epithelial adenocarcinoma (A549) cell lines were from Ammineae and Peucedaneae tribes while fruits fractions with high phenol contents and antioxidant powers were from Ammineae tribe. Conclusion: The Apiaceae fruits have significant biological effects, therefore the isolation of phytochemical compounds from active fractions with cytotoxicity is suggested in future studies.
عنوان نشريه :
گياهان دارويي
عنوان نشريه :
گياهان دارويي
