اﺛﺮات ﺗﻤﺮﯾﻦ ﺷﻨﺎ ﺑﺮ ﻓﺎﮐﺘﻮرﻫﺎي اﻟﺘﻬﺎﺑﯽ و اﺳﺘﺮس اﮐﺴﯿﺪاﺗﯿﻮ ﮐﻠﯿﻪﻫﺎ در ﻣﻮشﻫﺎي ﺻﺤﺮاﯾﯽ ﻣﺎده دﯾﺎﺑﺘﯽ و اوارﯾﮑﺘﻮﻣﯽﺷﺪه

Effects of Swim Training on Inflammatory Factors and Oxidative Stress of Kidneys in Diabetic and Ovariectomized Female Rats

ﺳﺎﺑﻘﻪ و ﻫﺪف: ﯾﺎﺋﺴﮕﯽ ﯾﮏ ﻓﺮآﯾﻨﺪ ﻓﯿﺰﯾﻮﻟﻮژﯾﮏ و دﯾﺎﺑﺖ ﯾﮏ ﺑﯿﻤﺎري ﻣﺘﺎﺑﻮﻟﯿﮏ اﺳﺖ ﮐﻪ در زﻧﺎن ﻣﯿﺎﻧﺴﺎل ﺑﺎ ﺷﯿﻮع ﺑﺎﻻﯾﯽ اﺗﻔﺎق ﻣﯽاﻓﺘﺪ. در اﯾﻦ ﻣﻄﺎﻟﻌﻪ اﺛﺮات ﺗﻤﺮﯾﻦ ﺷﻨﺎ ﺑﺮ ﺑﺮﺧﯽ از ﺷﺎﺧﺺﻫﺎي ﺑﯿﻮﺷﯿﻤﯿﺎﯾﯽ و ﻓﺎﮐﺘﻮرﻫﺎي ﻧﮑﺮوز ﺗﻮﻣﻮري آﻟﻔﺎ )TNF-α( و اﯾﻨﺘﺮﻟﻮﮐﯿﻦ6 )-IL( 6 ﺑﺎﻓﺖ ﮐﻠﯿﻪ در ﻣﻮشﻫﺎي ﺻﺤﺮاﯾﯽ اوارﯾﮑﺘﻮﻣﯽﺷﺪه و ﻣﺒﺘﻼ ﺑﻪ دﯾﺎﺑﺖ ﻣﻮرد ﺑﺮرﺳﯽ ﻗﺮار ﮔﺮﻓﺖ. ﻣﻮاد و روﺷﻬﺎ: در اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺗﺠﺮﺑﯽ 50 ﺳﺮ ﻣﻮش ﺻﺤﺮاﯾﯽ ﻣﺎده ﺑﺎﻟﻎ ﺑﻪ ﭘﻨﺞ ﮔﺮوه 10ﺗﺎﯾﯽ ﺗﻘﺴﯿﻢ و ﺑﻪ ﻣﺪت ﻫﺸﺖ ﻫﻔﺘﻪ ﺑﺮرﺳﯽ ﺷﺪﻧﺪ. ﮔﺮوه اول ﺷﺎﻫﺪ، ﮔﺮوه دوم اوارﯾﮑﺘﻮﻣﯽﺷﺪه )دوﻃﺮﻓﻪ(، ﮔﺮوه ﺳﻮم ﻣﻮشﻫﺎي اوراﯾﮑﺘﻮﻣﯽ دﯾﺎﺑﺘﯽ و ﮔﺮوه ﭼﻬﺎرم اوارﯾﮑﺘﻮﻣﯽ ﺑﺎ ﺗﻤﺮﯾﻦ ﺷﻨﺎ و ﮔﺮوه ﭘﻨﺠﻢ ﻣﻮشﻫﺎي اوارﯾﮑﺘﻮﻣﯽ دﯾﺎﺑﺘﯽ ﺑﺎ ﺗﻤﺮﯾﻦ ﺷﻨﺎ ﺑﻮدﻧﺪ. در اﻧﺘﻬﺎي دوره آزﻣﺎﯾﺶ ﻧﻤﻮﻧﻪﺑﺮداريﻫﺎي ﺑﺎﻓﺘﯽ ﺑﻪ اﻧﺠﺎم رﺳﯿﺪ و ﺗﻐﯿﯿﺮات ﻓﺎﮐﺘﻮرﻫﺎي ﺑﯿﻮﺷﯿﻤﯿﺎﯾﯽ و ﭘﯿﺶاﻟﺘﻬﺎﺑﯽ ﺑﺎﻓﺖ ﮐﻠﯿﻪﻫﺎ ﺗﻌﯿﯿﻦ ﺷﺪﻧﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﻏﻠﻈﺖ ﮔﻠﻮﮐﺰ ﺧﻮن در ﻣﻮشﻫﺎي ﺻﺤﺮاﯾﯽ دﯾﺎﺑﺘﯽ و اوارﯾﮑﺘﻮﻣﯽ دﯾﺎﺑﺘﯽ اﻓﺰاﯾﺶ داﺷﺖ )P<0/001(. ﻏﻠﻈﺖ ﻣﺎﻟﻮنديآﻟﺪﺋﯿﺪ در ﮔﺮوهﻫﺎي اوارﯾﮑﺘﻮﻣﯽ )0/025=P( و اوارﯾﮑﺘﻮﻣﯽ دﯾﺎﺑﺘﯽ )0/001

Background and Purpose: Menopause is a physiologic process and diabetes is a metabolic disease that occurs with high prevalence in old women. In this study effects of exercise training on some biochemical parameters and factors ofTumor necrosis factor alpha (TNF-α) andInterleukin 6(IL-6) investigated in ovariectomized and diabetic rats. Methodology: In this empirical study 50 mature female rats divided into five groups that 10 rats attributed to each group and were studied for eight weeks. The first as control group, the second group as ovariectomized (bilateral), third group as diabetic ovariectomized rats, fourth group as ovariectomized under swimming training, and fifth group as diabetic ovariectomized under swimming training rats. At the end experimental period, tissue sampling was performed and changes of biochemical and pre-inflammatory factors were determined. Results: The blood glucose concentration increased in diabetic and diabetic ovariectomized (p < 0.001). The concentration of malondialdehyde increased in ovariectomized (P=0.025) and diabetic ovariectomized (p < 0.001) groups and decreased with training (P=0.040). The activity of superoxide dismutase (P=0.021), glutathione peroxidase (P <0.001) and catalase (P=0.010) decreased in diabetic ovariectomized group, which increased with training. (P=0.023, P=0.041 and P=0.027, respectively). The pre inflammatory factors (TNF-α and IL-6) were increased in diabetic and diabetic ovariectomized groups (p < 0.001) while training decreased the increased amount of these factors. Conclusion: The menopause and diabetes lead to increasing of the renal pre inflammatory factors and harmful changing in the antioxidation enzymes. The aerobic training like as swimming can be used as an effective factor in improving these factors