تاثير تمرين هوازي بر پرپتين، آدروپين و مقاومت به انسولين در مردان داراي اضافه وزن عليرضا شيرويه ، فرشاد امامي ، محمد سنايي ، رسول طريقي

The Effect of Aerobic Training on Preptin, Adropin and Insulin Resistance in Overweight Men

زمينه و هدف: پرپتين و آدروپين هورمون‌هاي پپتيدي هستند كه با تنظيم متابوليسم كربوهيدرات‌ها نقش مهمي در كنترل چاقي دارند. هدف از پژوهش حاضر بررسي تاثير تمرين هوازي بر آدروپين، پرپتين و مقاومت به انسولين در مردان داراي اضافه وزن بود. روش كار: در اين مطالعه كارآزمايي باليني، 18 مرد داراي اضافه وزن و چاق (سن 3/92 ± 58/39، شاخص‌توده بدني 1/23±75//28) انتخاب و به­طور تصادفي به دو گروه (كنترل و تمرين) تقسيم شدند. گروه­هاي تمرين به ­مدت هشت هفته، هر هفته پنج جلسه در برنامه تمريني هوازي (با شدت 65 تا 85 درصد حداكثر ضربان قلب، 40 دقيقه) شركت كردند. دو روز قبل و بعد از اجراي پروتكل، در حالت ناشتا خون­گيري انجام شد. پرپتين و آدروپين به روش الايزا اندازه‌گيري شد. داده ها با استفاده از آزمون t مستقل و ANCOVA در سطح معني‌داري 0/05

Background & objectives: Preptin and adropine are peptide hormones that play an important role in the controlling of obesity by regulation of carbohydrate metabolism. The purpose of the present study was to investigate the effect of aerobic training on preptin, adropine and insulin resistance in men with overweight. Methods: In this clinical trial study, 18 overweight and obese men (age 58.39±3.92, body mass index 28.75±1.23) were selected and randomly divided into two groups (control and exercise). Exercise group participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 65 to 85% of maximum heart rate, 40 minutes). Two days before and after the protocol, fasting blood samples were taken. Preptin and adropine were measured by ELISA. Data were tested using independent t-test and ANCOVA at a significance level of p<0.05. Results: The level of preptin in the experimental group was significantly reduced compared to the control group (p=0.001) and the pretest (p=0.000). Also, the adropine level in the experimental group increased significantly compared to the control group (p=0.000) and the pretest (p=0.000). Also, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) values in the exercise group compared to the control group (p=0.000) and pretest (p=0.000) showed a significant decrease. Conclusions: Exercise improved glycemic index in obese and overweight men by improving the levels of preptin and adropine. It seems that aerobic exercise can be an effective intervention method to control and prevent the occurrence of metabolic diseases in these people.