عنوان مقاله :
شيوع سلياك در بيماران نوروپاتي
عنوان به زبان ديگر :
Celiac Disease in Patients with Neuropathy
پديد آورندگان :
Bijan ،Shahbazkhani Shariati Hospital - Tehran University of Medical Sciences - Tehran, Iran , Mohammad ،Abdehagh Shariati Hospital - Tehran University of Medical Sciences - Tehran, Iran , Shahriar ،Nafissi Neurology Department - Shariati Hospital - Tehran University of Medical Sciences - Tehran, Iran
كليدواژه :
Celiac disease , Neuropathy , Serological test
چكيده لاتين :
Background:
Neuropathy means nerve damage, which interferes with the functioning of the peripheral nervous system. It has been mentioned
as one of the extra-intestinal manifestations of celiac disease. This study aimed to investigate the prevalence of celiac disease in
patients presented with idiopathic neuropathy.
Materials and Methods:
A cross-sectional study was done in patients with idiopathic neuropathy at Shariati Hospital, Tehran. Serological tests including
endomysial IgA, tissue transglutaminase (TTG) IgA and IgG, and DGP (deamidated gliadin peptide) IgA, and genetic assessment
for HLA DQ2 and DQ8 (human leukocyte antigen) were done for all patients and those who had positive celiac serology and
HLA DQ2/DQ8 underwent endoscopy and adequate biopsy samples were taken. Diagnosis was made based on histopathological
report of celiac disease.
Results:
101 patients with idiopathic neuropathy were enrolled. The mean age was 43.56 ± 10.66 years (range 70-18 years). The prevalence
of HLA-DQ2 and HLA-DQ8 positivity in patients with idiopathic neuropathy was 36.6% and 9.9%, respectively. The most common
neuropathy subtype in patients with positive HLA-DQ2 and DQ8 was demyelinating PN (Polyneuropathy). One patient (1%) was
diagnosed as havine celiac disease.
Conclusion:
Although the prevalence of celiac disease in patients with idiopathic neuropathy was similar to the general population, having
considered the pravalence of celiac disease, treating this condition with gluten-free diet is of importance.
