مقايسه اثر عصاره ميوه گياه ويتاگنوس با بروموكريپتين و داستينكس برسطح پرولاكتين و ليپيدهاي سرمي تغييريافته در زنان مبتلا به هيپرپرولاكتينمي

The effect of Vitex Agnus castus extract on blood level of prolactin, & compare of its effects on the Lipids level with those of Bromocriptine and Dostinex in women with hyperprolactinemia

مقدمه هيپرپرولاكتينمي در زنان منجر به اختلال قاعدگي، آن اوولاسيون و آمنوره و كمبود پروژسترون پس از اوولاسيون مي شود. هدف از مطالعه حاضر بررسي تاثير عصاره گياه ويتاگنوس برسطح پرولاكتين خون و مقايسه اثرات آن بر ليپيدهاي سرمي تغييريافته در زنان هيپرپرولاكتينميك با بروموكريپتين و داستينكس بود. مواد و روش ها از ميان بيماران هيپرپرولاكتينميك مراكز درماني كه در سن باروري بودند، 105 نفر به طور تصادفي به سه گروه تقسيم و در مدت تحقيق (4 سيكل)، تحت درمان با بروموكريپتين، داستينكس و ويتاگنوس قرار گرفتند. طي اين مدت، غلظت سرمي پرولاكتين، كلسترول، LDL، HDL و تري گليسيريد اندازه گيري شد. يافته ها نتايج نشان داد كه به غير از بروموكريپتين در سايرگروه ها، در هر مرحله نسبت به مرحله قبل تفاوت آماري معني داري در ميزان پرولاكتين وجود داشت. در گروه بروموكريپتين از دو سيكل بعد از شروع درمان هر محله با مرحله قبل از درمان تفاوت معني داري نشان داد (0/05

Introduction Hyperprolactinemia in women results in menstrual disorders, irregular ovulation, amenorrhea, and reduction of progesterone Level after ovulation, due to corpus luteum failure. This study aimed at comparing the effect of Vitagnus fruit extract on blood prolactin level and its effect on altered serum lipids in Hyperprolactinemic women with Bromocriptine and Dustinex. Materials and Methods Among the women with Hyperprolactinemia referring to medical Centers, 105 subjects were chosen and classified into 3 groups: Bromocriptin Dustinex and Vitagnus. They were treated during (i.e. 4 cycles), and finally, the blood levels of prolactin, Cholesterol, HDL, LDL, triglycerides were measured. Results The results showed that, except in Bromocryptin, in other groups, there was a meaningful difference in each step compared to the earlier step in terms of prolactin level change. In the Bromocryptin group, after two cycles of treatment, each step showed a meaningful difference from the earlier step (p<0.05). examination of cholesterol levels showed that the reduction of cholesterol levels in various cycles was meaningful. In Dustinex group, there was observed meaningful difference in all steps except the final step of treatment. In the case of Vitagnus, the impact of treatment was meaningful, except in the first step. The results showed that all drugs had a meaningful effect on LDL level, after the third stage. The increase in serum HDL level for Vitagnus was more than other Tablets in all stages. Conclusion Vitagnus decreases the prolactin level meaningfully, Similar to Bromocryptin and Dustinx. Also decreased cholesterol, LDL, and triglyceride, wherever increased HDL level.