ميزان بروز عفونت مجدد با هكيلوباكترپيلوري سه سال پس از ريشه كني موفق آن

Helicobacter pylori reinfection rate 3 years after successful eradication

Introduction: Helicobacter pylori (HP) infection is one of the most prevalent human infections. It is the main cause of peptic ulcer disease and one of the predisposing factors .for gastric cancer. Reinfection rate after eradication is quite uncommon in adults, but in only study in Iran it has been 19.1% in one year. We have studied the rate of reinfection 3 years after successfid eradication. Methods: All patients with Helicobacter pylori eradication 3 years before the beginning the study and negative UBT test one year after eradication have re-called for completion of questionnaire and UBT lest. All UBT positive cases underwent endoscopy and antral biopsy was taken. for rapid unease test, and biopsies from stomach antrum and body was taken for pathological study. Results: Out of 98 patients enrolled into the study, 20 patients (20.4%) had positive UBT test, of 19 accepted endoscopy,4 cases had positive rapid urease test (4.1%) and all these patients with another patient had positive Helicobacter pylori pathology (5.1 %).There was significant improvement in clinical symptoms (pc0.005) after successful eradication of Helicobacter pylori which had sustained in 3 years of follow up. Conclusion: Reinfection rate 3 year after successful eradication of Helicobacter pylori in our region is 20.4% (_10.2% / year);; if we rely on to only one test result (UBT test). If we consider the result of another diagnostic test, this rate declines to 5.1% 2.3% /year)