بررسي سرواپيدميولوژيك توكسوپلاسموز در مادران باردار شهر تهران

Seroepidemilogical survey of toxoplasmosis in pregnant women in Tehran

congenital toxoplasmosis is one of the most serious infectious diseases peresented in children and newborns as a result of-mother affliction with Toxoplasma gondii parasite during pregnancy. To determine the infection level in pregnant women, blood samples from 4120 niothers(6-12 weeks of pregnancy) were collected and examined by Indirect Florescence Antibody Test (I. F.A.T). Out of 4120 individuals, 2804 were positive (68% and 1316 were negative (32%). Among seropositive women, those who had antibody tiler lower or equal to 1/400, were eliminated from the study, and those had antibody titer more or equal to 1/800 were followed up. In the next visit, these women (antibody titer>1/800) were sampled and tested. Some of them that had constant or decreasing antibody assay which is the evidence of infection before pregnancy, were eliminated from the study. Pregnant women that had increasing antibody titer which was the evidence of new infection were put under observation for antibody titer. Altogether, in this part of the study, there was only one toxoplasmic child and two cases of abortion. Sampling and testing were carried out regularly (16-24 weeks and 28-36 weeks of pregnancy) from the seronegative women (32%) during the pregnancy period, and those who became seropositive during the pregnancy period, (seroconverted -18 cases) were put on research. In addiation in this part, 8 children were observed with congenital toxoplasmosis and one case of abortion. Based on the results obtained from this study, risk of affliction of seronegative mothers during pregnancy is about 14 in 1000 and the probability of being toxoplasmic among the children with high risk mothers is 7 per 1000.