سالگرد تولد ژنوم انسان، ميراث دشوار: ژنوم انسان در بيست سالگي

HUMAN GENOME ANNIVERSARY, Complicated legacies: The human genome at 20

اﻣﺮوزه، ﻣﻴﻠﻴﻮنﻫﺎ ﻧﻔﺮ ﺑﻪ اﻃﻼﻋﺎت ژﻧﮕﺎﻧﻲ ﺧﻮد دﺳﺖﻳﺎﻓﺘﻪاﻧﺪ. اراﺋﻪ ﻣﺴﺘﻘﻴﻢ ﺧﺪﻣﺎت ژﻧﮕﺎﻧﻲ ﺑﻪ ﻣﺘﻘﺎﺿﻴﺎن و ﺗﻜﻤﻴﻞ آنﻫﺎ ﺑﺎ دادهﻫﺎي ﺑﺰرگ دﻳﮕﺮ، ﭘﻴﺶﻧﻮﻳﺲ ژﻧﮕﺎن اﻧﺴﺎن را ﻛﻪ ﺑﻪدرﺳﺘﻲ در ﻓﻮرﻳﻪ 2001 ﺑﻪﻋﻨﻮان ﻳﻚ دﺳﺘﺎورد اﺳﺘﺜﻨﺎﺋﻲ ﺟﺸﻦ ﮔﺮﻓﺘﻪ ﺷﺪ، ﻫﺮ ﭼﻪ ﺑﻴﺸﺘﺮ ﭘﻴﺶﭘﺎاﻓﺘﺎده و ﻣﻌﻤﻮﻟﻲ ﻣﻲﻛﻨﺪ. اﻣﺎ ﭼﻨﻴﻦ ﭘﻴﺸﺮﻓﺖﻫﺎي ﻋﻤﻠﻲ و ﻓﻨﻲِ ﻗﺎﺑﻞﺗﻮﺟﻬﻲ ﺑﺪون ﮔﺎمﻫﺎي اﺷﺘﺒﺎه و دردﺳﺮﻫﺎي ﻓﺰاﻳﻨﺪه ﻧﺒﻮده اﺳﺖ. ﻣﺠﻠﻪ ﺳﺎﻳﻨﺲ Science از ﻣﺘﺨﺼﺼﺎن زﻳﺮ ﺧﻮاﺳﺘﻪ اﺳﺖ ﺗﺎ ﺑﻪ ﻣﺎ در ﺑﺮرﺳﻲ اﻳﻨﻜﻪ ﭼﮕﻮﻧﻪ ﺑﻪ اﻳﻨﺠﺎ رﺳﻴﺪﻳﻢ و ﺑﻪ ﻛﺪام ﺳﻤﺖ ﺑﺎﻳﺪ ﺑﺮوﻳﻢ ﻳﺎ ﻧﺮوﻳﻢ، ﻛﻤﻚ ﻛﻨﻨﺪ.

Millions of people today have access to their personal genomic information. Direct-to-consumer services and integration with other “big data” increasingly commoditize what was rightly celebrated as a singular achievement in February 2001 when the first draft human genomes were published. But such remarkable technical and scientific progress has not been without its share of missteps and growing pains. Science invited the experts below to help explore how we got here and where we should (or ought not) be going.